Jiří Patočka

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In this work, the ability of four newly synthesized oximes--K005 (1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide), K027 (1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide), K033 (1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide) and K048 (1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane(More)
Humanin (HN) and its analogues have been shown to protect cells against death induced by various Alzheimer's disease (AD) genes and amyloid-beta-peptides in vitro; the analogues [Gly(14)]-HN and colivelin have also been shown to be potent in reversing learning and memory impairment induced by scopolamine or quinuclidinyl benzilate (QNB) in mice or rats in(More)
A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. Its inhibitory ability towards cholinesterases was determined and compared to tacrine (THA) and(More)
− snižovat aktivitu UDP-glukuronosyltrans-ferázy (UGT) a superoxiddismutázy (SOD) a současně inhibovat klastogenicitu vyvola-nou účinkem ionizačního záření (Saito et al., 2008) − inhibovat buněčnou proliferaci a indukovat apoptózu v různých rakovinných buňkách (Huang et al., 2007) − schopnost působit jako anti-atherogenní látky (Kim et al., 2007) a chránit(More)
1 Jihočeská univerzita v Českých Budějovicích, Zdravotně sociální fakulta, katedra radiologie a toxikologie 2 Univerzita Karlova v Praze, Přírodovědecká fakulta, katedra fyziologie živočichů a vývojové biologie Summary By smoking tobacco we mean inhalation of the smoke from burning dried tobacco leaves. This practice was common in many original inhabitants(More)
We investigated the relationship between the chemical structure of acetylcholinesterase (AChE; EC 3.1.1.7) reactivators and their potency in reactivating this enzyme, after prior inhibition by VX (O-ethyl-S-(2-diisopropylaminoethyl)-methylthiophosphonate), tabun, sarin, and cyclosarin. The oximes, pralidoxime (2-PAM), HI-6(More)
Advances in molecular biology along with improvements in electrophysiological techniques have increased the knowledge in the structure and function of many ion channels. Voltage-gated Na+ and K+ channels may become sensitive to biologically active substances such as animal toxins. Study of animal toxins can help to understand the molecular mechanisms of(More)
With prolongation of human age rises also the incidence of senile dementia, inclusive dementia of Alzheimer's type (DAT). At the same time the authors present views in the aetiology of this illness, the role of cholinergic mechanisms of the development dementia and they mention DAT treatment strategy focusing attention on a group of drugs-cholinesterase(More)