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Amitriptyline suppresses neuroinflammation and up-regulates glutamate transporters in morphine-tolerant rats
TLDR
The results show that amitriptyline not only attenuates morphine tolerance, but also preserves its antinociceptive effect. Expand
The Use of Dexamethasone for Preventing Postoperative Nausea and Vomiting in Females Undergoing Thyroidectomy: A Dose-Ranging Study
We sought to determine the minimum effective dose of dexamethasone in preventing postoperative nausea and vomiting in women undergoing thyroidectomy. Two hundred twenty-five women (n = 45 in each ofExpand
Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer.
Oral squamous cell carcinoma (OSCC) is a prevalent cancer worldwide. Let-7 family has been shown to function as a tumor suppressor through regulating multiple oncogenic signaling. Recent studyExpand
Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats
TLDR
The results suggest that the antiinflammatory effect of amitriptyline on morphine tolerance, probably acting by increasing IL-10 expression, is mediated by p38 mitogen-activated protein kinase heme oxygenase-1 signal transduction cascade. Expand
Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells.
TLDR
Data suggest that IL-8 and IL-32 play a role in regulating the CSC-like properties that promote tumorigenesis of CRCs in both autocrine and paracrine manners. Expand
Dexamethasone prevents postoperative nausea and vomiting: benefit versus risk.
Postoperative nausea and vomiting (PONV) is a common annoying experience after surgery. The overall incidence of PONV in adults is 20-30%; the incidence rate in patients of high-risk groups can be asExpand
Amitriptyline preserves morphine’s antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats
TLDR
Results show that acute amitriptyline treatment preserved morphine’s antinociceptive effect in morphine‐tolerant rats; the mechanisms may be involved in inhibition of phospho‐PKA and PKC expression, and thus inducing the GLAST and GLT‐1 trafficking onto glial cell surface which enhances the EAA uptake from the synaptic cleft and reduces EAA concentration in the spinal CSF. Expand
MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells
TLDR
It is shown that OGD can induce miR-210 expression through activating HIF-1α and miR -210 can mediate hypoxia-induced neural apoptosis by targeting Bcl-2. Expand
Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo
TLDR
Melatonin suppresses ischemia‐ and reperfusion‐induced ventricular arrhythmias and reduces infarct size resulting from I/R injury and the pronounced cardioprotective activity of melatonin may be mediated by its antioxidant activity and by its capacity for neutrophil inhibition in myocardial I/ R. Expand
Insomnia Subtypes and the Subsequent Risks of Stroke: Report From a Nationally Representative Cohort
TLDR
Insomnia predisposes individuals to increased risk of stroke and this association is profound among young adults, underscoring the clinical importance of identifying and treating insomnia. Expand
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