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Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias.

• Jurren M van Opstal, Jet D. M. Leunissen, Hem J. J. Wellens, M. A. Vos
• European journal of pharmacology
• 2001

Torsade de Pointes arrhythmias are a feared proarrhythmic effect of (antiarrhythmic) drugs. In dogs with chronic complete AV-block bradycardia-induced volume overload leads to electrical remodeling,… (More)

Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome.

• Jurren M van Opstal, M. Schoenmakers, +6 authors M. A. Vos
• Circulation
• 2001

BACKGROUND Amiodarone is an effective antiarrhythmic drug rarely associated with torsade de pointes arrhythmias (TdP). The noniodinated compound dronedarone could resemble amiodarone and be devoid of… (More)

Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes.

• Paul G. A. Volders, Karin Sipido, +4 authors Hem J. J. Wellens
• Circulation
• 1999

BACKGROUND Acquired QT prolongation enhances the susceptibility to torsades de pointes (TdP). Clinical and experimental studies indicate ventricular action potential prolongation, increased regional… (More)

Contractile adaptations preserving cardiac output predispose the hypertrophied canine heart to delayed afterdepolarization-dependent ventricular arrhythmias.

• S H Marieke De Groot, M. Schoenmakers, Mirella C Molenschot, Jet D. M. Leunissen, Hem J. J. Wellens, M. A. Vos
• Circulation
• 2000

BACKGROUND In dogs, chronic complete atrioventricular block (CAVB) results in structural (biventricular hypertrophy) and electrical (delayed repolarization) remodeling, which predisposes the heart to… (More)

The JT-Area Indicates Dispersion of Repolarization in Dogs with Atrioventricular Block

• Jurren M. van Opstal, S. Cora Verduyn, +4 authors Marc A. Vos
• Journal of Interventional Cardiac…
• 2002

Heterogeneity in cardiac repolarization (ΔAPD) is known to be arrhythmic. In the dog model of chronic complete AV-block and acquired long QT syndrome, an increase in ΔMAPD (defined as left… (More)

Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias.

• M. A. Vos, Jurren M van Opstal, Jet D. M. Leunissen, S. C. Verduyn
• Pharmacology & therapeutics
• 2001

When a new (cardiovascular) drug shows signs of QT interval prolongation on the ECG (delay in repolarization time), the regulatory agencies demand screening of its possible proarrhythmic potential… (More)

Time course of structural adaptations in chronic AV block dogs: evidence for differential ventricular remodeling.

• S. C. Verduyn, Christian R B Ramakers, G. Snoep, Jet D. M. Leunissen, Hem J. J. Wellens, M. A. Vos
• American journal of physiology. Heart and…
• 2001

To determine the nature and time course of biventricular hypertrophy and concomitant electrical and mechanical changes after creation of complete atrioventricular block (CAVB), six adult dogs (22-30… (More)

Observations on the onset of torsade de pointes arrhythmias in the acquired long QT syndrome.

• M. A. Vos, Bulent Gorenek, +4 authors Hem J. J. Wellens
• Cardiovascular research
• 2000

OBJECTIVE Premature ectopic beats may create a specific sequence of events (e.g. short-long-short) preceding Torsade de Pointes arrhythmias (TdP) in the long QT syndrome. The relevance of this… (More)

Action of MgSO4 differs from moricizine and verapamil on ouabain-induced ventricular tachycardia in normomagnesemic conscious dogs.

• M. A. Vos, Tomas Fazekas, Anton P. M. Gorgels, Jet D. M. Leunissen, Hem J. J. Wellens
• Journal of cardiovascular pharmacology
• 1994

We performed a comparative study to determine whether acute administration of MgSO4, moricizine, and verapamil to conscious dogs with normal plasma magnesium levels (0.75 +/- 0.06 mM) terminates… (More)

Premature escape beats. A model for triggered activity in the intact heart?

• M. A. Vos, Anton P. M. Gorgels, +4 authors Hem J. J. Wellens
• Circulation
• 1990

In conscious dogs with complete atrioventricular block, overdrive pacing of the idioventricular rhythm normally results in overdrive suppression (OS). Frequently, however, we observed another… (More)

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