Jesus A. Silvas

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UNLABELLED Recognition of viral pathogens by the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family results in the activation of type I interferon (IFN) responses. To avoid this response, most viruses have evolved strategies that target different essential steps in the activation of host innate immunity. In this study, we report that the(More)
Mayaro virus (MAYV), an alphavirus similar to chikungunya virus (CHIKV), causes an acute debilitating disease which results in the development of long-term arthralgia in more than 50% of infected individuals. Currently, the immune response and its role in the development of MAYV-induced persistent arthralgia remain unknown. In this study, we evaluated the(More)
Our genetic analyses of uncharacterized bunyaviruses isolated in Peru identified a possible reassortant virus containing small and large gene segment sequences closely related to the Caraparu virus and a medium gene segment sequence potentially derived from an unidentified group C orthobunyavirus. Neutralization tests confirmed serologic distinction among(More)
UNLABELLED Severe fever with thrombocytopenia syndrome (SFTS) virus is a newly recognized member of the genus Phlebovirus in the family Bunyaviridae. The virus was isolated from patients presenting with hemorrhagic manifestations and an initial case fatality rate of 12 to 30% was reported. Due to the recent emergence of this pathogen, there is limited(More)
We develop a linearized five dimensional Kaluza-Klein theory as a gauge theory. By perturbing the metric around flat and the De Sitter backgrounds, we first discuss linearized gravity as a gauge theory in any dimension. In the particular case of five dimensions, we show that using the Kaluza-Klein mechanism, the field equations of our approach implies both(More)
Severe fever with thrombocytopenia syndrome (SFTS) is a newly recognized hemorrhagic fever disease found throughout Asia with a case fatality rate between 12% and 30%. Since 2009, SFTS has been reported in China throughout 14 Chinese Provinces. In addition, SFTS has been recognized in South Korea and Japan with the first confirmed cases reported in 2012. A(More)
Novel static, time-dependent and spatial-temporal solutions of Einstein field equations, displaying singularities, with and without horizons, and in several dimensions are found based on a dimensional reduction procedure widely used in Kaluza-Klein type theories. The Kerr-Newman black-hole entropy as well as the Reissner-Nordstrom, Kerr and Schwarzschild(More)
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