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Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response.
The hypothalamo-pituitary-adrenocortical (HPA) axis is required for stress adaptation. Activation of the HPA axis causes secretion of glucocorticoids, which act on multiple organ systems to redirectExpand
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Ascending mechanisms of stress integration: Implications for brainstem regulation of neuroendocrine and behavioral stress responses
HighlightsBrainstem nuclei provide monosynaptic input to the paraventricular hypothalamus.These distinct cell groups signal through multiple transmitters and peptides.Integration of brainstem inputsExpand
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Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice
Ghrelin is a 28-amino acid polypeptide that regulates feeding, glucose metabolism, and emotionality (stress, anxiety, and depression). Plasma ghrelin circulates as desacyl ghrelin (DAG) or, in anExpand
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“Braking” the Prefrontal Cortex: The Role of Glucocorticoids and Interneurons in Stress Adaptation and Pathology
The medial prefrontal cortex (mPFC) receives information regarding stimuli and appropriately orchestrates neurophysiological, autonomic, and behavioral responses to stress. The cellular andExpand
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Conditional deletion of glucocorticoid receptors in rat brain results in sex-specific deficits in fear and coping behaviors
Glucocorticoid receptors (GR) have diverse functions relevant to maintenance of homeostasis and adaptation to environmental challenges. Understanding the importance of tissue-specific GR function inExpand
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Deletion of Glucocorticoid Receptors in Forebrain GABAergic Neurons Alters Acute Stress Responding and Passive Avoidance Behavior in Female Mice
The glucocorticoid receptor (GR) is critically involved in regulation of stress responses [inhibition of the hypothalamic-pituitary-adrenal (HPA) axis], emotional behavior and cognition viaExpand
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Prefrontal Cortex Regulates Chronic Stress‐Induced Cardiovascular Susceptibility
Background The medial prefrontal cortex is necessary for appropriate appraisal of stressful information, as well as coordinating visceral and behavioral processes. However, prolonged stress impairsExpand
Prefrontal Cortex Regulates Chronic Stress-Induced Cardiovascular Susceptibility
The medial prefrontal cortex (mPFC) is necessary for appropriate appraisal of stressful information, as well as coordinating visceral and behavioral processes. However, prolonged stress impairs mPFCExpand
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Infralimbic cortical glutamate output is necessary for the neural and behavioral consequences of chronic stress
Exposure to prolonged stress is a major risk-factor for psychiatric disorders such as generalized anxiety and major depressive disorder (MDD). Human imaging studies have identified structural andExpand
Use of CRISPR/Cas9 Gene Targeting to Conditionally Delete Glucocorticoid Receptors in Rat Brain
Glucocorticoid receptors (GR) have diverse functions relevant to maintenance of homeostasis and adaptation to environmental challenges. Understanding the importance of tissue-specific GR function inExpand