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Futile cycle of transcription initiation and termination modulates the response to nucleotide shortage in S. cerevisiae.
Hidden transcription in eukaryotes carries a large potential of regulatory functions that are only recently beginning to emerge. Cryptic unstable transcripts (CUTs) are generated by RNA polymerase IIExpand
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Roadblock termination by reb1p restricts cryptic and readthrough transcription.
Widely transcribed compact genomes must cope with the major challenge of frequent overlapping or concurrent transcription events. Efficient and timely transcription termination is crucial to controlExpand
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Results of an osteoporosis educational intervention randomized trial in a sample of Puerto-Rican women.
The purpose of this study was to determine the effects of an osteoporosis educational intervention on knowledge, health beliefs, and self-efficacy in college-age Puerto Rican women. The Health BeliefExpand
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Modulation of transcription affects mRNP quality.
Cotranscriptional loading of proteins onto nascent transcripts contributes to the formation of messenger ribonucleoprotein particles (mRNPs) competent for nuclear export. The transcription machineryExpand
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Cryptic Transcription and Early Termination in the Control of Gene Expression
Recent studies on yeast transcriptome have revealed the presence of a large set of RNA polymerase II transcripts mapping to intergenic and antisense regions or overlapping canonical genes. Most ofExpand
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High‐resolution transcription maps reveal the widespread impact of roadblock termination in yeast
Transcription termination delimits transcription units but also plays important roles in limiting pervasive transcription. We have previously shown that transcription termination occurs whenExpand
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Screening of suppressors of bax-induced cell death identifies glycerophosphate oxidase-1 as a mediator of debcl-induced apoptosis in Drosophila
Members of the Bcl-2 family are key elements of the apoptotic machinery. In mammals, this multigenic family contains about twenty members, which either promote or inhibit apoptosis. We haveExpand
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Mitochondria, Bcl-2 family proteins and apoptosomes: of worms, flies and men.
Initiator caspases are activated within specialized complexes, one of which is the apoptosome. The apoptosome is always constituted by at least an initiator caspase and a caspase activator.Expand
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Apoptosis in Drosophila: which role for mitochondria?
It is now well established that the mitochondrion is a central regulator of mammalian cell apoptosis. However, the importance of this organelle in non-mammalian apoptosis has long been regarded asExpand
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The drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the β-TrCP homologue slimb
The ubiquitin–proteasome system is one of the main proteolytic pathways. It inhibits apoptosis by degrading pro-apoptotic regulators, such as caspases or the tumor suppressor p53. However, it alsoExpand
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