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Absence of nicotinic acetylcholine receptor α7 subunit amplifies inflammation and accelerates onset of fibrosis: an inflammatory kidney model
Inflammation is regulated by endogenous mechanisms, including anti‐inflammatory cytokines, adenosine, and the nicotinic acetylcholine receptor α7 subunit (α7nAChR). We investigated the role ofExpand
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Opposing Activity Changes in AMP Deaminase and AMP-Activated Protein Kinase in the Hibernating Ground Squirrel
Hibernating animals develop fatty liver when active in summertime and undergo a switch to a fat oxidation state in the winter. We hypothesized that this switch might be determined by AMP and theExpand
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Macrophage A2A Adenosine Receptors Are Essential to Protect from Progressive Kidney Injury.
A2A adenosine receptors (A2ARs) are endogenous inhibitor of inflammation. Macrophages that are key effectors of kidney disease progression express A2ARs. We investigated the role of A2ARs in kidneyExpand
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Different effects of global osteopontin and macrophage osteopontin in glomerular injury.
Osteopontin (OPN) is a pro-and anti-inflammatory molecule that simultaneously attenuates oxidative stress. Both inflammation and oxidative stress play a role in the pathogenesis of glomerulonephritisExpand
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Endogenous Inhibitors of Kidney Inflammation.
Although inflammation is the physiological response to pathogen invasion and tissue damage, it can also be responsible for significant tissue damage. Therefore, the inflammatory response must beExpand
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Absence of nicotinic acetylcholine receptor a 7 subunit ampli fi es in fl ammation and accelerates onset of fi brosis : an in fl ammatory kidney model
Inflammation is regulated by endogenous mechanisms, including anti-inflammatory cytokines, adenosine, and the nicotinic acetylcholine receptor a7 subunit (a7nAChR). We investigated the role ofExpand