Jessica Myers

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INTRODUCTION The Orphan Drug Act encourages drug development for rare conditions. However, some orphan drugs become top sellers for unclear reasons. We sought to evaluate the extent and cost of approved and unapproved uses of orphan drugs with the highest unit sales. METHODS We assessed prescription patterns for four top-selling orphan drugs: lidocaine(More)
BACKGROUND Admission to a room previously occupied by a patient with certain multidrug-resistant organisms (MDROs) increases the risk of acquisition. Traditional cleaning strategies do not remove all environmental MDROs. We evaluated the environmental and clinical impact of hydrogen peroxide vapor (HPV) room disinfection. METHODS We performed a 30-month(More)
In recent years, the number of studies using a cluster-randomized design has grown dramatically. In addition, the cluster-randomized crossover design has been touted as a methodological advance that can increase efficiency of cluster-randomized studies in certain situations. While the cluster-randomized crossover trial has become a popular tool, standards(More)
BACKGROUND Antidepressant (AD) use has been purported to increase the risk of breast and ovarian cancer, although both epidemiological and pre-clinical studies have reported mixed results. Previous studies in a variety of biomedical fields have found that financial ties to drug companies are associated with favorable study conclusions. METHODS AND(More)
In an effort to promote a greater understanding of the voting systems that sit in the middle of the election technology spectrum-somewhere between hand counted paper ballots and Internet voting-this work presents a classification of the electronic voting technologies currently used in the U.S. A classification structure is presented and characteristics of(More)
Longitudinal healthcare claims databases are frequently used for studying the comparative safety and effectiveness of medications, but results from these studies may be biased due to residual confounding. It is unclear whether methods for confounding adjustment that have been shown to perform well in small, simple nonrandomized studies are applicable to the(More)
BACKGROUND Adjusting for laboratory test results may result in better confounding control when added to administrative claims data in the study of treatment effects. However, missing values can arise through several mechanisms. METHODS We studied the relationship between availability of outpatient lab test results, lab values, and patient and system(More)
Mismatches between electronic part procurement lifecycles and the lifecycles of the products they are used in causes products with long manufacturing and/or support lives to suffer from significant obsolescence management costs. Lifetime buy is a prevalent mitigation approach employed for electronic part obsolescence management. Making lifetime purchases of(More)
Propensity scores (PS) have been widely used in epidemiology to control for confounding bias in non-experimental comparative studies of drugs, but the technique of matching patients by score becomes computationally impractical with studies of three or more treatment groups. Imbens' generalized propensity score (GPS) provides a method for comparing multiple(More)