Jessica Myers

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INTRODUCTION The Orphan Drug Act encourages drug development for rare conditions. However, some orphan drugs become top sellers for unclear reasons. We sought to evaluate the extent and cost of approved and unapproved uses of orphan drugs with the highest unit sales. METHODS We assessed prescription patterns for four top-selling orphan drugs: lidocaine(More)
In recent years, the number of studies using a cluster-randomized design has grown dramatically. In addition, the cluster-randomized crossover design has been touted as a methodological advance that can increase efficiency of cluster-randomized studies in certain situations. While the cluster-randomized crossover trial has become a popular tool, standards(More)
BACKGROUND Antidepressant (AD) use has been purported to increase the risk of breast and ovarian cancer, although both epidemiological and pre-clinical studies have reported mixed results. Previous studies in a variety of biomedical fields have found that financial ties to drug companies are associated with favorable study conclusions. METHODS AND(More)
In an effort to promote a greater understanding of the voting systems that sit in the middle of the election technology spectrum-somewhere between hand counted paper ballots and Internet voting-this work presents a classification of the electronic voting technologies currently used in the U.S. A classification structure is presented and characteristics of(More)
BACKGROUND Adjusting for laboratory test results may result in better confounding control when added to administrative claims data in the study of treatment effects. However, missing values can arise through several mechanisms. METHODS We studied the relationship between availability of outpatient lab test results, lab values, and patient and system(More)
Longitudinal healthcare claims databases are frequently used for studying the comparative safety and effectiveness of medications, but results from these studies may be biased due to residual confounding. It is unclear whether methods for confounding adjustment that have been shown to perform well in small, simple nonrandomized studies are applicable to the(More)
The anterior cruciate ligament (ACL) is one of the most commonly injured ligaments, with over 250,000 injuries per year in the United States. Its primary function is to limit anterior tibial translation when the quadriceps muscle group contracts to extend the knee. Previous studies have found that ACL-deficient individuals avoid use of the quadriceps in the(More)
Sustainability means keeping an existing system operational and maintaining the ability to manufacture and field versions of the system that satisfy the original requirements. Sustainability also includes manufacturing and fielding revised versions of the system that satisfy evolving requirements, which often requires the replacement of technologies used in(More)
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