Jessica M Luis

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BACKGROUND The most deadly form of cancer is not lung or colon, breast or prostate; it is any cancer that has become metastatic. Mortality due to metastatic melanoma, one of the most aggressive and deadly cancers, has increased steadily over the last several decades. Unfortunately, the arsenal of chemotherapeutic agents available today is most often(More)
Autosomal dominant polycystic kidney disease (ADPKD) is genetically heterogeneous, with at least three chromosomal loci (PKD1, PKD2, and PKD3) accounting for the disease. Mutations in the PKD2 gene, on the long arm of chromosome 4, are estimated to be responsible for 15% of the cases of ADPKD, based on linkage studies. PKD2 is a milder form of the disease,(More)
Without treatment, disseminated disease and cryptococcal meningitis are almost invariably fatal. Treatment regimens recommended by the 2000 Infectious Disease Society of America practice guidelines for the management of cryptococcal disease depend on the presenceor absence ofCNS disease and theHIV status of the patient. The treatment of choice for(More)
A 62-year-old man presented with a 10-day history of painful ulcerated lesions on his tongue and penis. His medical history was remarkable for a low-risk myelodysplastic syndrome, which had been treated with antithymocyte globulin and cyclosporine 1 month earlier. Clinical examination showed a large, deep, and exquisitely tender ulceration on the glans(More)
A series of symmetrically substituted dibenzoyl furoxans were synthesized and investigated for their potential to release nitric oxide, which plays a key role in the nervous and cardiovascular systems. Cysteine was employed to promote nitric oxide release from furoxan via the formation of an S-nitrosothiol intermediate. Transition metal ion-mediated(More)
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