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In the technique known as gridding, the data samples are weighted for sampling density and convolved with a finite kernel, then resampled on a grid preparatory to a fast Fourier transform. The authors compare the artifact introduced into the image for various convolving functions of different sizes, including the Kaiser-Bessel window and the zero-order(More)
Serotonin produced by neuroendocrine tumors is believed to be a principal cause of the diarrhea in carcinoid syndrome. We assessed the safety and efficacy of telotristat etiprate, an oral serotonin synthesis inhibitor, in patients with diarrhea associated with carcinoid syndrome. In this prospective, randomized study, patients with evidence of carcinoid(More)
In flow-imaging experiments with 2-D Fourier transform sequences, the time difference between phase encoding and readout leads to a potentially misleading displacement artifact. This artifact arises in regions of rapid flow and high shear, and manifests as an intensity distortion in addition to a bulk shift. We have studied methods of mitigating the(More)
BACKGROUND & AIMS Serotonin (5-hydroxytryptamine [5-HT]) has an important role in gastrointestinal function. LX1031 is an oral, locally acting, small molecule inhibitor of tryptophan hydroxylase (TPH). Local inhibition of TPH in the gastrointestinal tract might reduce mucosal production of serotonin (5-HT) and be used to treat patients with nonconstipating(More)
We have studied a pulse sequence using compact imaging gradients for MR angiography by selective inversion recovery. By acquiring signals approaching a half-echo, we achieve significant immunity to artifacts from flow-induced dephasing. Initial clinical results on carotid arteries accurately depict stenoses without the problems of signal dephasing.
A problem with magnetic resonance angiograms of vessels containing irregular flow is that flow-induced dephasing can result in voids in the image. These void regions are susceptible to misinterpretation as regions of stenosis or other vessel pathology. Flow-induced dephasing can be minimized by using radial lines to cover k space. However, radial lines(More)
In magnetic resonance imaging, if the object of interest is known to be spatially bounded within the image field-of-view, then the high-intensity, low spatial frequencies can be determined by postprocessing. This allows the system receiver gain to be increased, thereby decreasing the quantitation noise from the analog-to-digital converters. No imaging(More)
PURPOSE Telotristat etiprate, a tryptophan hydroxylase inhibitor, was previously evaluated in a Phase II randomized, placebo-controlled clinical trial in patients with carcinoid syndrome (CS) and diarrhea not adequately controlled by octreotide. The objective of the current study was to characterize the symptom experiences of patients participating in that(More)
312 Background: Diarrhea associated with carcinoid syndrome (CS) has been attributed to tumor production of serotonin. Telotristat etiprate, (LX1032, LX1606), is an oral inhibitor of peripheral serotonin synthesis. This study explored the safety, tolerability, and efficacy of telotristat etiprate in carcinoid patients with octreotide-refractory diarrhea. (More)
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