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Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels
Significance Mechanobiology is receiving an increasing amount of focus, but the mechanics of cell-substrate behavior are often neglected in cell biology. As such, novel materials and systems that areExpand
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Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction
Significance Three-dimensional systems enable the formation of tissue-mimetic architectures and promote more realistic physiological responses than conventional 2D systems. Here we report aExpand
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Haptotaxis is Cell Type Specific and Limited by Substrate Adhesiveness
Motile cells navigate through tissue by relying on tactile cues from gradients provided by extracellular matrix such as ligand density or stiffness. Mesenchymal stem cells (MSCs) and fibroblastsExpand
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Dynamic and reversible surface topography influences cell morphology.
Microscale and nanoscale surface topography changes can influence cell functions, including morphology. Although in vitro responses to static topography are novel, cells in vivo constantly remodelExpand
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Density Gradient Multilayered Polymerization (DGMP): A Novel Technique for Creating Multi-compartment, Customizable Scaffolds for Tissue Engineering
Complex tissue culture matrices, in which types and concentrations of biological stimuli (e.g. growth factors, inhibitors, or small molecules) or matrix structure (e.g. composition, concentration, orExpand
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Separated Edge-Soliton Meditated Dynamic Switching of Vortex Chirality and Polarity.
Magnetic vortices are characterized by the senses of in-plane magnetization chirality and by the polarity of the vortex core. The electrical control of vortex polarity and chirality is highlyExpand
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Interplay of matrix sti ness and protein tethering in stem cell di erentiation
Stem cells regulate their fate by binding to, and contracting against, the extracellular matrix. Recently, it has been proposed that in addition to matrix sti ness and ligand type, the degree ofExpand
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Mesenchymal Stem Cells Duro- and Hapto- Taxis Alters Cell State
Anchorage dependent cells can sense and respond to extracellular matrix (ECM) stiffness, but stiffness gradients are often found in vivo via normal tissue variation or pathological conditions, suchExpand
Cell Mechanics on Surfaces
Cells have the amazing ability not only to sense how stiff their surrounding is but also to physically respond to changes in stiffness. Examples of this cellular response include migration followingExpand