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Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors
BACKGROUND Meiotic chromosome segregation in human oocytes is notoriously error-prone, especially with ageing. Such errors markedly reduce the reproductive chances of increasing numbers of womenExpand
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Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes
Female meiotic divisions are extremely asymmetric, producing large oocytes and small polar bodies (PBs). In mouse oocytes, the spindle relocates to the cortex before anaphase of meiosis I (MI). It isExpand
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Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types
SOX family proteins SOX2 and SOX18 have been reported as being essential in determining hair follicle type; however, the role they play during development remains unclear. Here, we demonstrate thatExpand
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Disruption of Spermatogenesis and Infertility in Ataxia with Oculomotor Apraxia Type 2 (AOA2)
Ataxia with oculomotor apraxia type 2 (AOA2) is a rare autosomal recessive cerebellar ataxia characterized by onset between 10 and 20 years of age and a range of neurological features that includeExpand
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Immunofluorescence Staining of K-Fibers in Mouse Oocytes Using Cold Fixation.
The kinetochore is a multiprotein complex that assembles on centromeric DNA and constitutes the main attachment interface between chromosomes and microtubules of the spindle apparatus. KinetochoresExpand
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Oocytes mount a noncanonical DNA damage response involving APC-Cdh1–mediated proteolysis
Using an in vivo model of DNA damage involving Senataxin knockout mice along with in vitrogenotoxic treatments, Subramanian et al. identify a DNA damage response in oocytes that builds slowlyExpand
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Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry
Meiotic divisions in oocytes are extremely asymmetric and require pre- and post-anaphase-onset phases of spindle migration. The latter induces membrane protrusion that is moulded around the spindleExpand
The Presence of Immature GV− Stage Oocytes during IVF/ICSI Is a Marker of Poor Oocyte Quality: A Pilot Study
Here we investigate whether the presence of germinal vesicle-stage oocytes (GV− oocytes) reflects poor oocyte developmental competence (or quality). This was a prospective, non-randomised, cohortExpand