Jessica E Dalsing-Hernandez

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Inflammatory activation of microglia in response to neurodegenerative changes in diseases such as Alzheimer's disease (AD) and Parkinson's disease has been extensively described. These observations have suggested that inflammation could be contributing to disease progression. In this paper, the potential role of CD200 and CD200 receptor (CD200R), whose(More)
A central feature of the inflammatory pathology in Alzheimer's disease is activated microglia clustered around aggregated amyloid beta (Abeta) peptide-containing plaques. In vitro-cultured microglia can be activated to an inflammatory state by aggregated Abeta with the induction of a range of different neurotoxic factors and provide a model system for(More)
Incidental Lewy body disease (ILBD) is the term used when Lewy bodies are found in the nervous system of subjects without clinically documented parkinsonism or dementia. The prevalence of ILBD in the elderly population has been estimated at between 3.8 and 30%, depending on subject age and anatomical site of sampling. It has been speculated that ILBD(More)
A central feature of the inflammatory pathology in Alzheimer's disease is activated mi-croglia clustered around aggregated amyloid ␤ (A␤) peptide-containing plaques. In vitro-cultured microglia can be activated to an inflamma-tory state by aggregated A␤ with the induction of a range of different neurotoxic factors and provide a model system for studying(More)
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