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Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector.
- P. Sinn, Jessica D. Goreham-Voss, +4 authors P. McCray
- Biology, Medicine
- Human gene therapy
- 14 December 2007
The practical application of gene transfer as a treatment for genetic diseases such as cystic fibrosis or hemophilia has been hindered, in part, by low efficiencies of vector delivery and transgene… Expand
808. Optimizing Non-Primate Lentiviral Vectors for Gene Transfer of CFTR to Airway Epithelia
Suboptimal expression from Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) cDNA delivered by viral vectors has, in part, limited the use of gene transfer as a therapy for cystic fibrosis.… Expand
339. FIV Lentiviral Vector Gene Transfer for Hemophilia A
Hemophilia A is an X-linked genetic disorder resulting in deficiencies in coagulation Factor VIII and a risk of sustained bleeding after trauma or injury. Hemophilia A is an attractive candidate for… Expand