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This is the PDF file of the manuscript that was accepted for publication. The manuscript have undergone copyediting, typesetting, and review of the resulting proof in its final form. Please note that during the production process, errors may had been discovered which may have affected the content, and all legal disclaimers that apply to the journal pertain.(More)
In temporal lobe epilepsy, seizures initiate in or near the hippocampus, which frequently displays loss of neurons, including inhibitory interneurons. It is unclear whether surviving interneurons function normally, are impaired, or develop compensatory mechanisms. We evaluated GABAergic interneurons in the hilus of the dentate gyrus of epileptic(More)
Software Product Line Engineering is becoming widely used due to the improvement it means when developing software products of the same family. The commonalities and variabilities of Software Product Lines (SPL) are identified during the Domain Engineering process and then, they are realized in the software architecture. Therefore, mechanisms to explicitly(More)
The handling of serotonin [5-hydroxytryptamine (5-HT)] depends on the serotonin transporter (SERT). A SERT knockout (KO) rat is a useful model to test the hypothesis that SERT is the primary mechanism for arterial 5-HT uptake and to investigate the impact of SERT removal on blood pressure. Wild-type (WT) and KO rats were used to measure 5-HT content(More)
Software systems need software architectures to improve their scalability and maintenance. However, many agile practitioners claim that the upfront design of software architectures is an investment that does not pay off, since customers can rarely appreciate the value delivered by architectures. Furthermore, conventional architectural practices may be(More)
Software architecture is a key factor to scale up Agile Software Development (ASD) in large software-intensive systems. Currently, software architectures are more often approached through mechanisms that enable to incrementally design and evolve software architectures (aka. agile architecting). Agile architecting should be a lightweight decision-making(More)
CMMI has been adopted advantageously in large companies for improvements in software quality, budget fulfilling, and customer satisfaction. However SPI strategies based on CMMI-DEV require heavy software development processes and large investments in terms of cost and time that medium/small companies do not deal with. The so-called light software(More)
Acceptance testing tools and Systems Under Test (SUT) require a gateway that will set up the communication link between them. Nevertheless, SUTs are often large systems composed of heterogeneous components that are executed in heterogeneous networks and platforms. Therefore, a non trivial communication problem between testing tools and these SUT(More)