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In temporal lobe epilepsy, seizures initiate in or near the hippocampus, which frequently displays loss of neurons, including inhibitory interneurons. It is unclear whether surviving interneurons function normally, are impaired, or develop compensatory mechanisms. We evaluated GABAergic interneurons in the hilus of the dentate gyrus of epileptic(More)
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Biological agents, particularly anti-Tumour Necrosis Factor (TNF)-α agents, have emerged as an effective treatment in patients with chronic inflammatory diseases. An association between anti-TNF-α antibodies and reactivation of latent tuberculosis infection (LTBI) has been established. Appropriate screening for TB infection has become mandatory before(More)
Software Product Line Engineering is becoming widely used due to the improvement it means when developing software products of the same family. The commonalities and variabilities of Software Product Lines (SPL) are identified during the Domain Engineering process and then, they are realized in the software architecture. Therefore, mechanisms to explicitly(More)
Interferon (IFN)-γ release assays (IGRAs) are probably the most accurate tests for the detection of latent Mycobacterium tuberculosis infection, but IGRAs are labour intensive and the transport of samples over longer distances is difficult. IFN-γ-induced protein (IP)-10 is expressed at 100-fold higher levels than IFN-γ, and IP-10 release assays have(More)
The aim of our work here was to evaluate the immunogenicity of 60 mycobacterial antigens, some of which have not been previously assessed, notably a novel series of in vivo-expressed Mycobacterium tuberculosis (IVE-TB) antigens. We enrolled 505 subjects and separated them in individuals with and without latent tuberculosis infection (LTBI) vs. patients with(More)
Software systems need software architectures to improve their scalability and maintenance. However, many agile practitioners claim that the upfront design of software architectures is an investment that does not pay off, since customers can rarely appreciate the value delivered by architectures. Furthermore, conventional architectural practices may be(More)
Software architecture is a key factor to scale up Agile Software Development (ASD) in large software-intensive systems. Currently, software architectures are more often approached through mechanisms that enable to incrementally design and evolve software architectures (aka. agile architecting). Agile architecting should be a lightweight decision-making(More)
CMMI has been adopted advantageously in large companies for improvements in software quality, budget fulfilling, and customer satisfaction. However SPI strategies based on CMMI-DEV require heavy software development processes and large investments in terms of cost and time that medium/small companies do not deal with. The so-called light software(More)