Jessica C Shen

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BACKGROUND Chronic rhinosinusitis is a multifactorial disease resulting in impaired mucociliary clearance. Recent literature suggests that different bacterial species are associated with varied disease severity. We examined the immediate effect of microbial secreted factors on sinonasal ciliary function. METHODS Murine primary sinonasal cultures were(More)
The relative potencies of various prostaglandins were investigated in trypsin-dispersed cat adrenocortical cells. Prostacyclin proved to be the most potent steroidogenic prostaglandin, being 100-1000 times more potent than PGE2. This stimulant effect of prostacyclin was only partially dependent upon the presence of extracellular calcium and was associated(More)
BACKGROUND Chronic rhinosinusitis is a multifactorial disease characterized by a local inflammatory response and impaired mucociliary clearance. Our prior work suggests that nonpolypoid inflammation can blunt ciliary dynamics. Thus, we set out to determine whether exogenously applied recombinant keratinocyte chemoattractant (KC), mouse homologue of(More)
Trypsin-dispersed cat adrenocortical cells were incubated at 37 degrees C in modified Eagle's medium containing [14C]arachidonic acid of sodium [14C]-acetate and then in non-radioactive medium. Radioactive incorporation was obtained in all phospholipids, with the greatest amount of radioactivity in phosphatidylcholine, followed by phosphatidylethanolamine,(More)
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