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Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. We previously reported the discovery… (More)
Overexpression of prosurvival proteins such as Bcl-2 and Bcl-X L has been correlated with tumorigenesis and resistance to chemotherapy, and thus, the development of antagonists of these proteins may… (More)
PURPOSE The purpose of this study was to characterize the activity of the Bcl-2 protein family inhibitor ABT-263 in a panel of small cell lung cancer (SCLC) xenograft models. EXPERIMENTAL DESIGN A… (More)
ABT-263 is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins with a K i of ≤ 1 nM against Bcl-2, Bcl-X L , and Bcl-w. Potent cytotoxic effects have been demonstrated against… (More)