Jesse Yenchih Hsu

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Although subjects with chronic kidney disease (CKD) are at markedly increased risk for cardiovascular mortality, the relation between CKD and aortic valve calcification has not been fully elucidated. Also, few data are available on the relation of aortic valve calcification and earlier stages of CKD. We sought to assess the relation of aortic valve calcium(More)
We congratulate Drs. Laber, Lizotte, Qian, Pelham and Murphy on an outstanding review of dynamic treatment regimes (DTRs). This group has done pioneering work in advancing the theory and applications of DTRs. In a DTR, the treatment type and level are repeatedly adjusted according to an individual’s need. An important part of designing DTRs is to choose(More)
that discover effect modification by exploratory methods Jesse Y. Hsu1, José R. Zubizarreta, Dylan S. Small, Paul R. Rosenbaum University of Pennsylvania and Columbia University Abstract. An effect modifier is a pretreatment covariate such that the magnitude of the treatment effect or its stability changes with the level of the covariate. Generally, other(More)
In medical sciences, statistical analyses based on observational studies are common phenomena. One peril of drawing inferences about the effect of a treatment on subjects using observational studies is the lack of randomized assignment of subjects to the treatment. After adjusting for measured pretreatment covariates, perhaps by matching, a sensitivity(More)
in Observational Studies Jesse Y. Hsu1, Dylan S. Small, Paul R. Rosenbaum University of Pennsylvania, Philadelphia Summary. In an observational study of treatment effects, subjects are not randomly assigned to treatment or control, so differing outcomes in treated and control groups may reflect a bias from nonrandom assignment rather than a treatment(More)
A frequent concern in making statistical inference for causal effects of a policy or treatment based on observational studies is that there are unmeasured confounding variables. The instrumental variable method is an approach to estimating a causal relationship in the presence of unmeasured confounding variables. A valid instrumental variable needs to be(More)
INTRODUCTION The failure to rescue (FTR) rate is the probability of death after a major complication and was defined in elective surgical cohorts. In elective surgery, the precedence rate (proportion of deaths preceded by major complications) approaches 100%, but recent studies in trauma report rates of only 20-25%. We hypothesised that use of high quality(More)
Although recommended approaches to CKD management are achieved less often in Hispanics than in non-Hispanics, whether long-term outcomes differ between these groups is unclear. In a prospective longitudinal analysis of participants enrolled into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies, we used Cox proportional hazards models(More)
Cardiovascular events, such as hospitalizations because of congestive heart failure, often occur repeatedly in patients with CKD. Many studies focus on analyses of the first occurrence of these events, and discard subsequent information. In this article, we review a number of statistical methods for analyzing ordered recurrent events of the same type,(More)
BACKGROUND Admission physiology predicts mortality after injury, but may be improved by resuscitation before transfer. This phenomenon, which has been termed lead-time bias, may lead to underprediction of mortality in transferred patients and inaccurate benchmarking in centers receiving large numbers of transfer patients. We sought to determine the impact(More)