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OBJECTIVES To conduct surveillance for neural tube defects (NTDs) in a high-risk region of the United States and to prevent occurrence and recurrence of NTDs through the periconceptional use of folic acid supplements. DESIGN Active and passive methods were used for surveillance of NTD-affected pregnancies and births during a 6-year period (October(More)
We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As(More)
We collected data on growth, psychomotor development, speech and language development, and intellectual function on a cohort of 100 males with the fragile X chromosome and 95 carrier females. The data include information on prenatal growth (33 males), growth during the preadult years (32 males), psychomotor development during the first 2 years (25 males),(More)
Active and passive surveillance methods were utilized in an attempt to identify all neural tube defect (NTD)-affected pregnancies in South Carolina, a state previously identified to have a high prevalence of these defects (Greenberg et al., 1983). Sources of case ascertainment included maternal serum alpha-fetoprotein (MSAFP) programmes, prenatal diagnosis(More)
OBJECTIVE To assess the effect on the human sex ratio at birth by assisted reproductive technology (ART) procedures. DESIGN Retrospective population-based study. SETTING Fertility clinics in Australia and New Zealand. POPULATION The study included 13,368 babies by 13,165 women who had a single embryo transfer (SET) between 2002 and 2006. METHODS(More)
OBJECTIVES To describe a 10-year trend in preterm birth. DESIGN Population-based study. SETTING Australia. POPULATION All women who gave birth during 1994-03. METHODS The proportion of spontaneous preterm births (greater than or equal to 22 weeks of gestation and less than 37 completed weeks of gestation) was calculated by dividing the number of(More)
PROBLEM/CONDITION The reported prevalence of anencephaly and spina bifida in the United States has steadily declined since the late 1960s. During this time, the ability to diagnose these defects prenatally has progressed rapidly. Many U.S. birth defects surveillance systems ascertain defects only among live-born infants or among infants and fetuses beyond a(More)
Folic acid absorption was compared in nonpregnant women with a history of pregnancy with a neural tube defect (cases)(n = 10) with that of control women (n = 10) with a normal pregnancy history. [2H4]folic acid was administered in an oral dose (400 micrograms) to fasting case and control subjects after a 30-d saturation protocol involving daily ingestion of(More)
BACKGROUND People with intellectual disability (ID) experience health inequity compared with the general population, a key contributing factor being disparities in social determinants of health. The enactment of the United Nations Convention on the Rights of Persons with Disabilities (CRPD) provides a platform for the progression and promotion of health and(More)
BACKGROUND Health assessments for people with intellectual disability have been implemented in the UK, New Zealand and Australia, and have led to improved health outcomes. The Comprehensive Health Assessment Program (CHAP) has been shown to improve the health of people with intellectual disability. Similar to other health assessments, it is designed to(More)