Jesse C. Craig

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A systematic review and meta-analysis was performed to evaluate the benefits and harms of antifungal prophylaxis in liver transplant recipients. Ten randomised trials comparing any prophylactic antifungal regimen with no antifungal agent or with another antifungal regimen were identified from Medline, EMBASE, the Cochrane Library, and other sources.(More)
BACKGROUND The increased incidence of skin cancers after solid organ transplantation is well recognized. Skin cancers developing in transplant recipients are more aggressive in behaviour. Therapeutic options to reduce and/or delay the development of cutaneous neoplasms are therefore of interest. OBJECTIVES The objective of this review was to summarize the(More)
We applaud Keir et al. (4) for their undertaking of a thorough study that investigated the association between several physiological phenomena and the threshold of sustainable exercise (i.e., critical power (CP)). This demarcation of sustainable exercise holds critical significance to applied and clinical exercise physiology, and the conclusion of the(More)
The highest sustainable rate of aerobic metabolism [critical power (CP)] and the finite amount of work that can be performed above CP (W' [curvature constant]) were determined under two muscle contraction duty cycles. Eight men completed at least three constant-power handgrip tests to exhaustion to determine CP and W' for 50% and 20% duty cycles, while(More)
Chronic heart failure (CHF) results in central and peripheral derangements that ultimately reduce skeletal muscle O2 delivery and impair exercise tolerance. Dietary nitrate (NO3 (-)) supplementation improves skeletal muscle vascular function and tolerance to exercise. We tested the hypothesis that NO3 (-) supplementation would elevate exercising skeletal(More)
It has previously been postulated that the anaerobic work capacity (W') may be utilized during resting blood flow occlusion in the absence of mechanical work. We tested the hypothesis that W' would not be utilized during an initial range of time following the onset of resting blood flow occlusion, after which W' would be utilized progressively more. Seven(More)
Tactile patterns were generated by means of a 6 X 24 array of vibrating pins. The ability of subjects to recognize these patterns presented to their fingertips was shown to be affected by a number of factors, including the display time of the pattern, the mode of generating the tactile patterns, the temporal relationship between the pattern to be identified(More)
The sustainable duration of severe intensity exercise is well-predicted by critical power (CP) and the curvature constant (W'). The development of the W'BAL model allows for the pattern of W' expenditure and reconstitution to be characterized and this model has been applied to intermittent exercise protocols. The purpose of this investigation was to assess(More)
The vascular ATP-sensitive K+ (KATP) channel is a mediator of skeletal muscle microvascular oxygenation (PO2mv) during contractions in health. We tested the hypothesis that KATP channel function is preserved in chronic heart failure (CHF) and therefore its inhibition would reduce PO2mv and exacerbate the time taken to reach the PO2mv steady-state during(More)
BACKGROUND Aerobic exercise capacity provides information regarding cardiorespiratory health and physical capacity. However, in many populations the ability to measure whole-body or leg aerobic exercise capacity is limited due to physical disability or lack of appropriate equipment. Clinically there is a need to evaluate aerobic capacity in individuals who(More)