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Distinct TLR- and NLR-Mediated Transcriptional Responses to an Intracellular Pathogen

• Jess H. Leber, Gregory T. Crimmins, Sridharan Raghavan, Nicole P Meyer-Morse, J. Stan Cox, Daniel A Portnoy
• PLoS pathogens
• 2008

How the innate immune system tailors specific responses to diverse microbial infections is not well understood. Cells use a limited number of host receptors and signaling pathways to both… (More)

The multidomain structure of Orc1 p reveals similarity to regulators of DNA replication and transcriptional silencing

• Stephen P Bell, W. J. Mitchell, Jess H. Leber, Ryuji Kobayashi, Bruce W. Stillman
• Cell
• 1995

The origin recognition complex (ORC) is a six protein assembly that binds S. cerevisiae origins of replication and directs DNA replication throughout the genome and transcriptional silencing at the… (More)

Block of HAC1 mRNA Translation by Long-Range Base Pairing Is Released by Cytoplasmic Splicing upon Induction of the Unfolded Protein Response

• Ursula Rüegsegger, Jess H. Leber, Peter J. Walter
• Cell
• 2001

Expression of the yeast transcription factor Hac1p, which controls the unfolded protein response, is regulated posttranscriptionally. Hac1p is only produced when an intron at the 3' end of its mRNA… (More)

IRE1-Independent Gain Control of the Unfolded Protein Response

• Jess H. Leber, Sebastián Bernales, Peter J. Walter
• PLoS biology
• 2004

Nonconventional splicing of the gene encoding the Hac1p transcription activator regulates the unfolded protein response (UPR) in Saccharomyces cerevisiae. This simple on/off switch contrasts with a… (More)

Activation of the integrated stress response during T helper cell differentiation

• Stefanie Scheu, Daniel B. Stetson, R Lee Reinhardt, Jess H. Leber, Markus Mohrs, Richard M Locksley
• Nature Immunology
• 2006

Adaptive immune responses require clonal expansion and differentiation of naive T cells into cytokine-secreting effector cells. After priming via signals through the T cell receptor, naive T helper… (More)

Development of a mariner-based transposon and identification of Listeria monocytogenes determinants, including the peptidyl-prolyl isomerase PrsA2, that contribute to its hemolytic phenotype.

• Jason Zemansky, Benjamin C Kline, Joshua J Woodward, Jess H. Leber, Hélène Marquis, Daniel A Portnoy
• Journal of bacteriology
• 2009

Listeriolysin O (LLO) is a pore-forming toxin that mediates phagosomal escape and cell-to-cell spread of the intracellular pathogen Listeria monocytogenes. In order to identify factors that control… (More)

Hyperinduction of host beta interferon by a Listeria monocytogenes strain naturally overexpressing the multidrug efflux pump MdrT.

• Kierstyn T Schwartz, Joshua D Carleton, Sarah Jane Quillin, Stuart D. Rollins, Daniel A Portnoy, Jess H. Leber
• Infection and immunity
• 2012

Many pathogens regulate or modify their immune-stimulating ligands to avoid detection by their infected hosts. Listeria monocytogenes, a facultative intracellular bacterial pathogen, interacts with… (More)

The novel Listeria monocytogenes bile sensor BrtA controls expression of the cholic acid efflux pump MdrT.

• Sarah Jane Quillin, Kierstyn T Schwartz, Jess H. Leber
• Molecular microbiology
• 2011

Mammalian bile has potent anti-microbial activity, yet bacterial pathogens of the gastrointestinal tract and hepatobiliary system nonetheless persist and replicate within bile-rich environments.… (More)

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