BACKGROUND The excess mortality associated with depressive disorders has been most often attributed to risks for suicide but diverse findings indicate that depressive disorders also increase risks for cardiovascular (CV) mortality. Among the possible mediators is the hypothalamic-pituitary-adrenal (HPA)-axis hyperactivity that characterizes many cases of… (More)
OBJECTIVE Anxiety predicts cardiovascular events, although the mechanism remains unclear. We hypothesized that anxiety symptoms will correlate with impaired resistance and conduit vessel function in participants aged 55 to 90 years. METHODS Anxiety symptoms were measured with the Symptom Checklist-90--Revised in 89 participants with clinically diagnosed… (More)
Recommended Citation Zhang, Tao. "Discrepancy-based algorithms for best-subset model selection." PhD (Doctor of Philosophy) thesis, ABSTRACT The selection of a best-subset regression model from a candidate family is a common problem that arises in many analyses. In best-subset model selection, we consider all possible subsets of regressor variables; thus,… (More)
Proton magnetic resonance spectroscopy is used to measure several metabolites in cortical gray and white matter in patients with Huntington's disease. The preliminary results show that CAG-repeat length correlates with white-matter N-acetylaspartate concentrations, and disease severity correlates with several metabolites.