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- Angela Manegold Svendsen, Anna Zalesko, Julie Kønig, Milka Vrecl, Anders Heding, Jesper Bøggild Kristensen +4 others
- Molecular and cellular endocrinology
- 2008

H2 relaxin, a member of the insulin superfamily, binds to the G-protein-coupled receptor RXFP1 (relaxin family peptide 1), a receptor that belongs to the leucine-rich repeat (LRR)-containing subgroup (LGRs) of class A GPCRs. We recently demonstrated negative cooperativity in INSL3 binding to RXFP2 and showed that this subgroup of GPCRs functions as… (More)

The longest common extension (LCE) problem is to prepro-cess a string in order to allow for a large number of LCE queries, such that the queries are efficient. The LCE value, LCEs(i, j), is the length of the longest common prefix of the pair of suffixes starting at index i and j in the string s. The LCE problem can be solved in linear space with constant… (More)

The fluorometric microculture cytotoxicity assay (FMCA) was employed for analysing the effect of different chemotherapeutic drug combinations and their single constituents in 44 cases of acute myelocytic leukaemia (AML). A large heterogeneity with respect to cell kill was observed for all combinations tested, the interactions ranging from antagonistic to… (More)

- H. Fridborg, B. Jonsson, P. Nygren, K. Csoka, K. Nilsson, G. Oberg +4 others
- British journal of cancer
- 1994

The semiautomated fluorimetric microculture cytotoxicity assay (FMCA) was used for evaluation of the ability of cyclosporin A (CsA) and its novel non-immunosuppressive derivative SDZ PSC 833 (PSC) to modify the response to doxorubicin or vincristine in vitro in different haematological and solid human tumour types. Primary cultures of 322 tumour samples… (More)

Liraglutide is a human glucagon-like peptide-1 (GLP-1) analogue approved for the treatment of type 2 diabetes. It is based on human GLP-1 with the addition of a 16-carbon fatty acid, which facilitates binding to plasma proteins, thus prolonging the elimination half-life and allowing once-daily administration. It has not been possible to quantify liraglutide… (More)

Parametrized surrogate models are used in alloy modeling to quickly obtain otherwise expensive properties such as quantum mechanical energies, and thereafter used to optimize, or simply compute, some alloy quantity of interest, e.g., a phase transition, subject to given constraints. Once learned on a data set, the surrogate can compute alloy properties… (More)

- Jesper Kristensen, Nicholas J Zabaras
- 2014

The cluster expansion enables fast alloy property computations especially useful for predicting alloy thermodynamics. It expands configurational alloy properties in basis functions called clusters with associated expansion coefficients called effective cluster interactions (ECI). The number of ECI depends on the symmetries of the system. Therefore, when… (More)

Cluster expansions are simplified, Ising-like models for binary alloys in which vibrational and electronic degrees of freedom are coarse grained. The usual practice is to learn the parameters of the cluster expansion by fitting the energy they predict to a finite set of ab initio calculations. In some cases, experiments suggest that such approaches may lead… (More)

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