Jesús Vega

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The tight junction constitutes the major barrier to solute and water flow through the paracellular space of epithelia and endothelia. It is formed by transmembrane proteins and submembranous molecules such as the MAGUKs ZOs. We have previously found that several MAGUKs, including those of the tight (ZO-1, ZO-2, and ZO-3) and septate junction (tamou and(More)
Cutaneous lesions caused by the pine processionary caterpillar Thaumetopoea pityocampa (TP) are frequent in pinewood areas. In the present study, 30 patients diagnosed with occupational immunologic urticaria from this caterpillar were included. Immediate hypersensitivity was demonstrated by performing prick and IgE-immunoblotting tests. Workers were grouped(More)
Epithelia in multicellular organisms constitute the frontier with the environment. Hence, epithelial cells are specialized in regulating the transit of ions and molecules from and into the organism. Therapeutic agents in order to reach their targets frequently need to cross epithelial sheets. Two routes are available for such purpose: the transcellular and(More)
BACKGROUND Thaumetopoea pityocampa [pine processionary moth (PPM)] is one of the most important lepidopteran agents causing urticant cutaneous reactions in humans in Mediterranean countries. This species is also expanding northwards, because of global warming. OBJECTIVES To investigate the prevalence, distribution by habitat group and possible risk(More)
Most of the information on the structure and function of the tight junction (TJ) has been obtained in MDCK cells. Accordingly, we have sequenced ZO-1 in this cell type, because this protein is involved in the response of the TJ to changes in Ca2+, phosphorylation, and the cytoskeleton. ZO-1 of MDCK cells comprises 6805 bp with a predicted open reading frame(More)
BACKGROUND Setae from Thaumetopoea pityocampa larvae (the pine processionary moth or PPM) can induce hypersensitivity reactions, but their clinical role in IgE-mediated responses is still subject to discussion. The aim of this study was to evaluate a setae extract for in vivo and in vitro diagnosis in nonhospitalized patients with reactions to PPM. (More)
Cationic currents in mature MDCK cells are almost exclusively due to K+ channels. Harvesting with trypsin-EDTA destroys 80-90% of these channels. Upon replating, K+ currents recover in 12-20 h, by means a process that requires synthesis of proteins and of RNA. In the present work we demonstrate that this restoration depends on a Ca2+ activated-cell contact.(More)
OBJECTIVE To present a case of spontaneous renal arteriovenous fistula treated at the Hospital Regional General No. 1 "Gabriel Mancera" of the Instituto Mexicano del Seguro Social (IMSS). CASE REPORT A 27-year-old female with no pathologic-medical background who presented with total, intermittent, macroscopic hematuria with clots as the only symptom(More)
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