Jesús P Paredes

Learn More
Deposition of plaques containing amyloid beta (Abeta) peptides is a neuropathological hallmark of Alzheimer's disease (AD). Here we demonstrate that neuronal overexpression of the epsilon isozyme of PKC decreases Abeta levels, plaque burden, and plaque-associated neuritic dystrophy and reactive astrocytosis in transgenic mice expressing familial AD-mutant(More)
The protein kinase C (PKC) family of serine-threonine kinases has been implicated in behavioral responses to opiates, but little is known about the individual PKC isozymes involved. Here, we show that mice lacking PKCepsilon have increased sensitivity to the rewarding effects of morphine, revealed as the expression of place preference and intravenous(More)
OBJECTIVE To examine whether colostomy closure is an operation with a high risk of complications. DESIGN Retrospective study of colostomy closures in a 14-year period. PARTICIPANTS 60 patients, averaging 54 years, males in 63%. The main indication for colostomy was colorectal neoplasm (47%), followed by trauma (23%). RESULTS There were 15 Hartman's(More)
The authors present a prospective study of the variations in sensitivity that appear in the armpit and arm after the intercostobrachial nerve has been sectioned in a modified radical mastectomy. Of a total of 208 patients studied between 1978 and 1987, the intercostobrachial nerve was sectioned in 139 patients, whereas in 30 it remained intact; in 39(More)
This report comprises a study of splenic autotransplantation in omental pouches in rats. Twenty six rats were operated. The spleen (50%) was transplanted after splenectomy in four different fragments. The animals were re-explored after periods between 3 and 5 1/2 months and the splenic implants retrieved for histological examination as well as size and(More)
INTRODUCTION The increasing aging of the population also increases the prevalence of symptomatic gallbladder diseases. It is important to analyse their surgical treatment in the elderly. METHODS All the laparoscopic cholecystectomies performed in our surgery department on patients aged 80 years-old or over from 1992 to 2007 were included in this study. (More)
  • 1