Jesús Pérez-Garrido

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BACKGROUND Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-degrading enzyme that suppresses T-lymphocyte activity. Costimulation blockade through CTLA4lg increases IDO in antigen-presenting cells. The suppressive effect of IDO is thought to be mediated by Foxp3+CD4+CD25+ regulatory T-cells (Tregs). OBJECTIVE In this descriptive study, we evaluated the(More)
1. At the median post-transplant follow-up (to Ab evaluation) of 51.4 months, the prevalence of anti-HLA and anti-MICA Abs was 21.9% and 19%, respectively. 2. Overall, of the 196 patients included, 124 (63.3%) were negative to all tested Abs, and 72 (36.7%) were positive for: HLA Abs alone = 34; MICA Abs alone = 29; and HLA + MICAAbs = 9. 3. Two years after(More)
BACKGROUND HLA and MICA antibodies are increasingly associated with poorer graft survival. The aim of this study is to report the frequency of graft loss 2 years after the detection of HLA abs and MICA abs among a group of kidney transplant recipients. METHODS We tested 196 patients with a functioning graft. Sera were screened for HLA and MICA IgG abs by(More)
UNLABELLED HLA alloantibodies (Abs) are associated with chronic rejection and poorer graft survival. The current study was designed to document the prevalence of HLA Abs in a group of kidney transplant recipients (KTR) and its impact on graft function. PATIENTS AND METHODS 283 KTR transplanted between January 1990 and December 2003 who had a functional(More)
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