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The objective of this 6-week, 120-patient, double-blind, randomized, controlled trial was to investigate if a foam dressing with ibuprofen provided clinically relevant pain relief (PAR) for exuding, painful venous leg ulcers in comparison with a similar foam dressing without ibuprofen. Primary outcome parameter was PAR compared with baseline pain during the(More)
1. Dose-response curves for noradrenaline, phenylephrine and clonidine were determined isometrically in 2-mm cylindrical segments from human skin arteries at 24 degrees C and compared to those previously reported at 37 degrees C. 2. Noradrenaline (3 x 10(-10)-3 x 10(-4) M) induced dose-dependent contraction and the sensitivity was increased during cooling.(More)
The effects of cooling on the isometric response of rabbit isolated central ear (cutaneous) and femoral (non-cutaneous) arteries to histamine were determined at 37 degrees C and 24 degrees C (cooling). Under resting tension, both types of arteries contracted to histamine (10(-7)-10(-3) M), and the sensitivity of ear arteries, but not of femoral arteries was(More)
BACKGROUND Hyaluronic acid (HA) (Restylane and Hylaform) is becoming more widely used for cosmetic procedures such as lip augmentation and treatment of facial skin lines, as other products, mainly bovine collagen, have proved allergenic in many patients. OBJECTIVE To report a case of a 48-year-old woman who developed discrete nodules in the lips after HA(More)
Experiments were performed to characterize the postjunctional alpha adrenoceptors that mediate adrenergic constriction in human skin arteries. Abdominal s.c. arteries were obtained from patients who died 3 to 12 hr before, and vascular segments 2 mm in length and 600 to 1050 microns in external diameter were prepared for isometric tension recording. On(More)
BACKGROUND Leishmaniasis, an endemic infection in Spain, is caused by protozoan parasites of the Leishmania genus. Between 2010 and 2012, there was an outbreak of cutaneous and visceral leishmaniasis in Fuenlabrada, Madrid. OBJECTIVES To describe the cases of cutaneous leishmaniasis diagnosed over a 17-month period at the dermatology department of(More)
BACKGROUND The pentavalent antimonials are considered the first-choice drugs for treatment of leishmaniasis. Intralesional therapy is used to minimize the systemic effects of the drug. METHODS Seventy patients were treated with weekly intralesional infiltrations of Glucantime(®) (meglumine antimoniate) for cutaneous leishmaniasis. Nine of them had(More)