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The alpha2/delta1 subunit forms part of the dihydropyridine receptor, an essential protein complex for excitation-contraction (EC) coupling in skeletal muscle. Because of the lack of a viable knock-out animal, little is known regarding the role of the alpha2/delta1 subunit in EC coupling or in other cell functions. Interestingly, the alpha2/delta1 appears(More)
Differential effects of n-3 and n-6 polyunsaturated fatty acids (PUFAs) have been demonstrated on adipose tissue physiology. Facing to the widely recognized beneficial effects of n-3 PUFAs, the n-6 PUFA effects remain controversial. Thus, we further analyzed the linoleic acid (LA) influence on adipocyte functions. To this aim, we treated by LA(More)
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To activate skeletal muscle contraction, action potentials must be sensed by dihydropyridine receptors (DHPRs) in the T tubule, which signal the Ca(2+) release channels or ryanodine receptors (RyRs) in the sarcoplasmic reticulum (SR) to open. We demonstrate here an inhibitory effect of the T tubule on the production of sparks of Ca(2+) release. Murine(More)
Most adult mammalian skeletal muscles contain only one isoform of ryanodine receptor (RyR1), whereas neonatal muscles contain two isoforms (RyR1 and RyR3). Membrane depolarization fails to evoke calcium release in muscle cells lacking RyR1, demonstrating an essential role for this isoform in excitation-contraction coupling. In contrast, the role of RyR3 is(More)
The recent interest in the surveillance of public, military, and commercial scenarios is increasing the need to develop and deploy intelligent and/or automated distributed visual surveillance systems. Many applications based on distributed resources use the so-called software agent technology. In this paper, a multi-agent framework is applied to coordinate(More)
This paper describes some key points of a new tool being currently developed by Eurocontrol for the assessment of air traffic control (ATC) multisensor trackers performance. It summarizes the algorithmic foundations of the high-accuracy trajectory reconstruction process used to obtain reference trajectories from recorded measures. These trajectories will(More)
Maritime surveillance involves gathering and integrating a large amount of heterogeneous information of variable quality to provide diverse decision makers with reliable knowledge about situations and threats. This requires information processing at all fusion levels while taking into account contextual information. Context is especially important for(More)