Jerry Drexler

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Intracellular localization and routing of MHC class II molecules and the associated invariant chain (Ii) were studied using rat-2 cells and HeLa cells stably transfected with the murine class II genes A alpha kA beta k (Ak) alone or supertransfected with human Ii or a truncated delta 20Ii lacking the endosomal sorting signal within Ii. We show that Ii and(More)
Pituitary thyrotrope tumours are a rare cause of hyperthyroidism. Prior in vitro studies of these tumours have revealed various patterns of differentiation and secretory activity. We have characterized the histological, biochemical, molecular and physiological features of a thyrotrope adenoma in order to define its origin and autonomy. Histochemical and(More)
The MHC class II-associated invariant chain (Ii) is involved in the intracellular sorting of class II molecules to the endocytic pathway where peptides from processed exogenous antigens are bound, and thereby Ii is thought to enhance antigen presentation. Here we demonstrate that presentation of only one out of five epitopes of a given antigen is augmented(More)
In normal antigen-presenting cells, newly synthesized major histocompatibility complex (MHC) class II molecules associate with the invariant chain (Ii) glycoprotein in the endoplasmic reticulum (ER). They are loaded with peptides only after proteolytic removal of the Ii in post-Golgi endocytic vesicles. Since the Ii inhibits peptide binding to MHC class II(More)
By JERRY DREXLER A DEFINITE RELATIONSHIP has never been established between indole metabolism and the megoloblastic anemias. Rhoads and associates”2 were able to produce a hemolytic-like anemia with many features of pernicious anemia, in dogs on vitamin B deficient diets, by the oral administration of pure indole. Interestingly, the relief of this anemia by(More)
Fasting plasma cyclic adenosine monophosphate (cAMP) was measured in 50 matureonset diabetic patients and in 111 non-diabetic patients. Methods used to determine plasma cAMP are described. The addition of sepharose agar beads to the bovine adrenocortical binding protein has considerably improved the sensitivity and simplified the radioligand-receptor assay(More)
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