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  • Jerry Cacia, Rodney G. Keck, Leonard G. Presta, J. Frenz
  • Chemistry, Medicine
  • Biochemistry
  • 1996
  • This report describes the effect on antigen binding of an isomerized aspartate residue located in the complementarity-determining regions (CDRs) of a recombinant monoclonal antibody. The antibody,Continue Reading
  • Tina M. Larson, Martin Gawlitzek, Heather N. Evans, Urs Albers, Jerry Cacia
  • Chemistry, Medicine
  • Biotechnology and bioengineering
  • 2002 (First Publication: 5 March 2002)
  • An on-line high-pressure liquid chromatography (HPLC) system capable of measuring amino acids and carbohydrates was used to study metabolism in mammalian cell culture systems. The HPLC methodContinue Reading
  • Atsushi Nishikawa, Walter Gregory, J. Frenz, Jerry Cacia, Stuart Kornfeld
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1997 (First Publication: 1 August 1997)
  • The secretory glycoprotein DNase I acquires mannose 6-phosphate moieties on its Asn-linked oligosaccharides, indicating that it is a substrate for UDP-GlcNAc:lysosomalContinue Reading
  • Jerry Cacia, Cynthia P. Quan, Mark Vasser, Mary B. Sliwkowski, J. Frenz
  • Chemistry, Medicine
  • Journal of chromatography
  • 1993 (First Publication: 1 March 1993)
  • Chromatographic separations can be tailored to exploit specific interactions between a stationary phase ligand and a protein structural feature of interest. Variations in this feature then form theContinue Reading
  • Hong-fu Wan, S M Kaneshiro, J. Frenz, Jerry Cacia
  • Chemistry, Medicine
  • Journal of chromatography. A
  • 2001 (First Publication: 1 April 2001)
  • This report describes a simple and rapid method to determine the relative amounts of glycoforms differing in terminal galactose on a recombinant antibody produced in Chinese hamster ovary (CHO)Continue Reading