Jerry Avorn

Robert J Glynn7
Aaron S. Kesselheim6
Kenneth J Rothman6
Til Stürmer4
7Robert J Glynn
6Aaron S. Kesselheim
6Kenneth J Rothman
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BACKGROUND The relationship between health professionals and the pharmaceutical industry has become a source of controversy. Physicians' attitudes towards the industry can form early in their careers, but little is known about this key stage of development. METHODS AND FINDINGS We performed a systematic review reported according to PRISMA guidelines to(More)
BACKGROUND Randomized trials aimed at improving the quality of medical care often randomize the provider. Such trials are frequently embedded in health care systems with available automated records, which can be used to enhance the design of the trial. METHODS We consider how available information from automated records can address each of the following(More)
BACKGROUND Nonexperimental studies of drug effects in large automated databases can provide timely assessment of real-life drug use, but are prone to confounding by variables that are not contained in these databases and thus cannot be controlled. OBJECTIVES To describe how information on additional confounders from validation studies can help address the(More)
BACKGROUND The goal of restricting study populations is to make patients more homogeneous regarding potential confounding factors and treatment effects and thereby achieve less biased effect estimates. OBJECTIVES This article describes increasing levels of restrictions for use in pharmacoepidemiology and examines to what extent they change rate ratio(More)
INTRODUCTION Health care utilisation ('claims') databases contain information about millions of patients and are an important source of information for a variety of study types. However, they typically do not contain information about disease severity. The goal of the present study was to develop a health care claims index for rheumatoid arthritis (RA)(More)
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The objective of this work was to assess the convergent validity of a previously developed rheumatoid arthritis medical records-based index of severity (RARBIS) by comparing it with the 28-joint Disease Activity Score (DAS28).(More)
BACKGROUND Generic prescription drugs are bioequivalent to brand-name versions but may not have consistent color or shape, which can cause confusion and lead to interruptions in medication use. We sought to determine whether switching among different-appearing antiepileptic drugs (AEDs) is associated with increased rates of medication nonpersistence, which(More)
Confounding can be a major source of bias in nonexperimental research. The authors recently introduced propensity score calibration (PSC), which combines propensity scores and regression calibration to address confounding by variables unobserved in the main study by using variables observed in a validation study. Here, the authors assess the performance of(More)
INTRODUCTION Preterm birth is a major contributor to neonatal morbidity and mortality and its rate has been increasing over the past two decades. Antidepressant medication use during pregnancy has also been rising, with rates up to 7.5% in the US. The objective was to systematically review the literature to determine the strength of the available evidence(More)
BACKGROUND Litigation documents reveal that pharmaceutical companies have paid physicians to promote off-label uses of their products through a number of different avenues. It is unknown whether physicians and scientists who have such conflicts of interest adequately disclose such relationships in the scientific publications they author. METHODS AND(More)