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The antimicrobial peptide LL-37 belongs to the cathelicidin family and is the first amphipathic alpha-helical peptide isolated from human. LL-37 is considered to play an important role in the first line of defence against local infection and systemic invasion of pathogens at sites of inflammation and wounds. Understanding its mode of action may assist in(More)
Sixty patients with chronic pain of the low back or cervical spine concomitant with clinical depression were studied in a 6-week, randomized, double-blind comparison of doxepin and placebo. Significant improvements in the doxepin-treated group compared to placebo or to baseline values were seen on Hamilton depression scores, Global Assessment Scale scores,(More)
BACKGROUND Levobupivacaine, the levo-enantiomer of bupivacaine, is as potent as bupivacaine but less toxic. Therefore, the authors investigated the efficacy, safety, and pharmacokinetics of perioperative epidural levobupivacaine with and without fentanyl in children. METHODS After Research Ethics Board approval and informed written consent, 120 healthy(More)
To the Editor:—Firth and Head 1 1 are to be congratulated for providing a comprehensive review of the pathophysiology of sickle cell disease and erudite discussion of its implications for anesthesiologists. We also appreciate their attempts to apply evidence-based knowledge to our understanding of the perioperative care of these patients. Although this will(More)
In 2007, the FDA advisory committee on anesthesia recommended that «children less than 3 years of age not undergo elective procedures» because of concerns regarding anesthetic toxicity (1). The vast majority of the evidence upon which that recommendation was based on young rodents and primates. These studies implicated virtually every available anesthetic(More)
U ncuffed tracheal tubes (TTs) have been the standard for tracheal intubation in infants and children for decades until the recent introduction of the Microcuff (Kim-berley-clark, Roswell, GA) cuffed TT. evidence suggests that the incidence of perioperative airway events after use of these new TTs is small, 1,2 although the evidence for their safe use in(More)
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