Jerome Moreaux

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The six-transmembrane epithelial antigen of prostate (STEAP) protein was identified in advanced prostate cancer and is up-regulated in multiple cancer cell lines, including prostate, bladder, colon, ovarian, and Ewing sarcoma. STEAP1 was described as a suitable antigen for T-cell-based or antibody-based immunotherapy. We have investigated the expression of(More)
RECQ helicase family members act as guardians of the genome to assure proper DNA metabolism in response to genotoxic stress. Hematological malignancies are characterized by genomic instability that is possibly related to underlying defects in DNA repair of genomic stability maintenance. We have investigated the expression of RECQ helicases in different(More)
Multiple myeloma (MM) is a plasma–cell malignancy with a high degree of biological and genetic heterogeneity at presentation and a great variability in terms of clinical outcome in response to chemotherapy. Over the last decades, the incorporation of novel agents (immunomod-ulatory drugs and proteasome inhibitors) with high-dose chemotherapy followed by(More)
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