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Clustering techniques have been used by many intelligent software agents in order to retrieve, lter, and categorize documents available on the World Wide Web. Clustering is also useful in extracting salient features of related web documents to automatically formulate queries and search for other similar documents on the Web. Traditional clustering(More)
We present WebACE, an agent for exploring and categorizing documents on the World Wide Web based on a user proole. The heart of the agent is an unsupervised cat-egorization of a set of documents, combined with a process for generating new queries that is used to search for new related documents and for ltering the resulting documents to extract the ones(More)
We propose an agent for exploring and categorizing documents on the World Wide Web based on a user proole. The heart of the agent is an automatic categorization of a set of documents, combined with a process for generating new queries used to search for new related documents and lter-ing the resulting documents to extract the set of documents most closely(More)
Clustering techniques have been used by many i n telligent software agents in order to retrieve, lter, and categorize documents available on the World Wide Web. Clustering is also useful in extracting salient features of related web documents to automatically formulate queries and search for other similar documents on the Web. Traditional clustering(More)
A novel recombinant human growth hormone (rhGH) fusion protein (VRS-317) was designed to minimize receptor-mediated clearance through a reduction in receptor binding without mutations to rhGH by genetically fusing with XTEN amino acid sequences to the N-terminus and the C-terminus of the native hGH sequence. Although in vitro potency of VRS-317 was reduced(More)
BACKGROUND Administration of daily recombinant human GH (rhGH) poses a considerable challenge to patient compliance. Reduced dosing frequency may improve treatment adherence and potentially overall treatment outcomes. OBJECTIVES This study assessed the safety and tolerability and the potential for achieving IGF-I levels within the target range in adults(More)
SUPINE hypotension is a common complication of late pregnancy and is due to the compression of the abdominal aorta and inferior vena cava between the spine and the gravid uterus.' Tilting the patient to the left or right displaces the uterus and relieves the pressure on the major vessels. A case is reported where this manoeuvre failed. The patient was a(More)
The time course of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neuroscience Letters, 363, 43-48. Akama KT, McEwen BS. Gene therapy to bet on: protecting neurons from stress hormones. Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat(More)
CONTEXT Somavaratan (VRS-317) is a long-acting form of recombinant human GH under development for children and adults with GH deficiency (GHD). OBJECTIVES To determine the optimal somavaratan dose regimen to normalize IGF-1 in pediatric GHD and to evaluate safety and efficacy of somavaratan over 6 months. DESIGN Open-label, multicenter, single ascending(More)
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