Jerome E. Mitchell

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We show that oligonucleotides of CNG tracts readily adopt compact DNA structures that move unusually fast on gels. Base composition does not explain this, and non-CNG triplets (including GNC) do not form such structures. Chemical probing and melting experiments suggest that the structures probably are not hairpins. Although both long and short tracts can(More)
Climate models that predict polar ice sheet behavior require accurate measurements of the bedrock-ice and ice-air boundaries in ground-penetrating radar imagery. Identifying these features is typically performed by hand, which can be tedious and error prone. We propose an approach for automatically estimating layer boundaries by viewing this task as a(More)
The near surface layer signatures in polar firn are preserved from the glaciological behaviors of past climate and are important to understanding the rapidly changing polar ice sheets. Identifying and tracing near surface internal layers in snow radar echograms can be used to produce high-resolution accumulation maps. This process is typically performed(More)
The dynamic responses of the polar ice sheets in Greenland and Antarctica can have substantial impacts on sea level rise. Understanding the mass balance requires accurate assessments of the bedrock and surface layers, but identifying each layer is performed subjectively by time-consuming, dense hand selection. We have developed an approach for(More)
A knowledge of parallel and distributed computing is important for students needing to address big data problems in later jobs in industry or academia. However, many campuses do not offer courses in these important areas due to curriculum limitations, a lack of faculty expertise, and limited instructional computing resources. MOOCs and Clouds provide an(More)
In order to satisfy qualifying exam requirements adhered to by the School of Informatics and Computing, I will provide an overview of global optimization techniques, specifically simulated annealing, genetic algorithms, and tabu seach.
The shift to parallel computing -- including multi-core computer architectures, cloud distributed computing, and generalpurpose GPU programming -- leads to fundamental changes in the design of software and systems. As a result, learning parallel, distributed, and cloud techniques in order to allow software to take advantage of the shift toward parallelism(More)
The Charles Creek area in Elizabeth City, NC experiences frequent flood conditions seemingly unrelated to rainfall amounts. The purpose of this study was to compare barometric pressures, lunar cycles, wind directions, and wind speeds with water depth readings of Charles Creek (a tributary of the Pasquotank River). A static remote imaging system was used to(More)
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