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Incidence of Thyroid-Related Adverse Events in Melanoma Patients Treated With Pembrolizumab
TLDR
Thyrotoxicosis compatible with inflammatory thyroiditis was associated with diffuse increased 18FDG uptake by the thyroid gland, and Serial measurements of thyroid function tests are indicated during anti-PD-1 monoclonal antibody therapy. Expand
A Systematic Review and Meta-Analysis of Endocrine-Related Adverse Events Associated with Immune Checkpoint Inhibitors.
TLDR
A meta-analysis shows a high incidence of endocrine adverse events provoked by single agent checkpoint blockade, further reinforced by combined treatment, and combination therapy was associated with ahigh incidence of hypothyroidism. Expand
Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review
TLDR
ICI-related diabetes mellitus is a rare but often life-threatening metabolic urgency of which health-care professionals and patients should be aware. Expand
Immune checkpoint inhibitor therapy for ACTH-secreting pituitary carcinoma: a new emerging treatment?
TLDR
Immune checkpoint inhibitors (ICI) therapy could be a promising treatment option for pituitary carcinoma, considering the mechanisms of TMZ-induced hypermutation with increased immunogenicity, pituitsary expression of CTLA-4 and PD-L1, and the frequent occurrence of hypophysitis as a side effect of ICI therapy. Expand
Successful Pretreatment Using Plasma Exchange before Thyroidectomy in a Patient with Amiodarone-Induced Thyrotoxicosis
TLDR
Therapeutic plasma exchange (TPE) is successful in rapidly restoring a clinical and biochemical euthyroid state, and may be used to decrease the perioperative risks associated with thyroidectomy in patients with life-threatening thyrotoxicosis or in cases refractory to medical treatment. Expand
Coronavirus disease 2019–related Kawasaki-like disease in an adult: A case report
TLDR
This report describes a similar case in an adult caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including a Kawasaki-like disease in children. Expand
Polyneuropathy in a young Belgian patient: A novel heterozygous mutation in the WNK1/HSN2 gene
TLDR
2 new heterozygous mutations in the WNK1/HSN2 gene are described in a Belgian patient with early-onset sensory polyneuropathy, characterized by loss of pain and loss of temperature and touch sensation. Expand
Acute Heart Failure as a First Presentation of Pheochromocytoma Complicated with “Inverted” Takotsubo Syndrome
TLDR
A 43-year-old formerly healthy patient with an adrenal pheochromocytoma is described, presenting as an “inverted” takotsubo syndrome complicated with acute heart failure and pulmonary oedema. Expand
SUN-923 Combination Immune Checkpoint Inhibitor Therapy for ACTH-Secreting Pituitary Carcinoma
TLDR
The disease status of the patient is stable up until now, suggesting at least disease control by the immunotherapy, suggesting checkpoint blockade inhibitors are a promising novel treatment modality for refractory pituitary tumors. Expand