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OBJECTIVE To improve the accuracy and completeness of reporting of studies of diagnostic accuracy in order to allow readers to assess the potential for bias in the study and to evaluate its generalisability. METHODS The Standards for Reporting of Diagnostic Accuracy (STARD) steering committee searched the literature to identify publications on the(More)
Diagnostic testing can be used to discriminate subjects with a target disorder from subjects without it. Several indicators of diagnostic performance have been proposed, such as sensitivity and specificity. Using paired indicators can be a disadvantage in comparing the performance of competing tests, especially if one test does not outperform the other on(More)
OBJECTIVE To assess the discriminative capacity of Chlamydia antibody titers in the diagnosis of tubed pathology in subfertile patients. DESIGN Meta-analysis of studies comparing Chlamydia antibody titers and laparoscopy for tubal patency and peritubal adhesions. PATIENTS A total of 2,729 patients with subfertility in 23 studies. INTERVENTION(S)(More)
The quality of reporting of studies of diagnostic accuracy is less than optimal. Complete and accurate reporting is necessary to enable readers to assess the potential for bias in the study and to evaluate the generalisability of the results. A group of scientists and editors has developed the STARD (Standards for Reporting of Diagnostic Accuracy) statement(More)
CONTEXT The literature contains a large number of potential biases in the evaluation of diagnostic tests. Strict application of appropriate methodological criteria would invalidate the clinical application of most study results. OBJECTIVE To empirically determine the quantitative effect of study design shortcomings on estimates of diagnostic accuracy. (More)
It is indispensable for any meta-analysis that potential sources of heterogeneity are examined, before one considers pooling the results of primary studies into summary estimates with enhanced precision. In reviews of studies on the diagnostic accuracy of tests, variability beyond chance can be attributed to between-study differences in the selected(More)
OBJECTIVE To explore designs for evaluating the prognostic and predictive value of medical tests and their effect on patient outcome. STUDY DESIGN Theoretical analysis with examples from the medical literature. RESULTS For evaluating the prognostic value of a test, one can include the test at baseline in prognostic studies. To evaluate the value of test(More)
The objective of the 'Standards for Reporting of Diagnostic Accuracy' (STARD) initiative is to improve the reporting of studies of diagnostic accuracy, so as to allow readers to assess the potential for bias in a study and to evaluate the generalibility of its results. The group searched the literature to identify publications on the appropriate conduct and(More)
OBJECTIVE To assess the diagnostic performance of serum CA-125 measurement in the detection of endometriosis. DESIGN Meta-analysis. SETTING AND PATIENT(S) Twenty-three studies comparing serum CA-125 levels and laparoscopically confirmed endometriosis. INTERVENTION(S) Serum CA-125 measurement and laparoscopy. MAIN OUTCOME MEASURE(S) Sensitivity and(More)
BACKGROUND Evidence is limited regarding the most effective pharmacological treatment for psychotic depression: combination of an antidepressant plus an antipsychotic, monotherapy with an antidepressant or monotherapy with an antipsychotic. This is an update of a review first published in 2005 and last updated in 2009. OBJECTIVES 1. To compare the(More)