Jeroen D. E. van Suijlen

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PURPOSE To evaluate whether cystatin C in serum (sCyC) and urine (uCyC) can predict early acute kidney injury (AKI) in a mixed heterogeneous intensive care unit (ICU), and also whether these biomarkers can predict the need for renal replacement therapy (RRT). METHODS Multicenter prospective observational cohort study in patients ≥18 years old and with(More)
The new selective access analysis system BM/Hitachi 917 was evaluated in an international multicentre study, mainly according to the ECCLS protocol for the evaluation of analysers in clinical chemistry. Forty-three different analytes, covering 56 different methods--enzymes, substrates, electrolytes, specific proteins, drugs and urine applications--were(More)
In a previous report in Clinical Chemistry, we described much higher international normalized ratios (INRs) 1 with recombinant Neoplastin R (Roche Diagnostics) than with tissue-extract Neoplastin Plus (Roche Diagnostics) in patients initiating oral anticoagulant therapy (1). For patients on stable oral anticoagulation, we observed no significant differences(More)
With the introduction of high-sensitive assays, cardiac troponins became potential biomarkers for risk stratification and prognostic medicine. Observational studies have reported an inverse association between physical activity and basal cardiac troponin levels. However, causality has never been demonstrated. This study investigated whether basal cardiac(More)
A recently introduced blood gas/electrolyte analyzer (SenDx 100((R)), renamed ABL70) intended for point-of-care, near-patient, or stat laboratory use was evaluated simultaneously in four different institutions and compared with three different laboratory bench analyzers with respect to imprecision, inaccuracy (assessed by tonometry), and patient-sample(More)
A candidate reference method is described for coupled sodium-water determination based on ion-exchange sodium separation from the serum matrix followed by gravimetry as Na2SO4, and serum water determination by means of microwave evaporation. For sera with normal sodium and water contents, the mean relative standard deviation is 0.6% (0.8 mmol/l). Mean(More)
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