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Crossing-over ensures accurate chromosome segregation during meiosis, and every pair of chromosomes obtains at least one crossover, even though the majority of recombination sites yield non-crossovers. A putative regulator of crossing-over is RNF212, which is associated with variation in crossover rates in humans. We show that mouse RNF212 is essential for(More)
Intraspecific genomes can be subdivided into blocks with limited diversity. Understanding the distribution and structure of these blocks will help to unravel many biological problems including the identification of genes associated with complex diseases, finding the ancestral origins of a given population, and localizing regions of historical recombination,(More)
We have developed a novel tool for visualizing and analyzing multiple collinear genomes. Unlike previous genome browsers and viewers, ours allows for simultaneous and comparative analysis. Our browser is web-based and provides intuitive selection and interactive navigation about features of interest. Dynamic visualizations adjust to scale and data content(More)
In mid-2007 Chromosome Research will be publishing the 10th in its series of themed issues on the topic of Meiosis, guest edited by James Turner, Medical Research Council, Mill Hill, London, UK. We hope it will be published as issue 4 of Volume 15. It would be hard to imagine a selection of articles that better represents the current highly exciting state(More)
Controlled independent manipulation of multiple objects at cellular length scales in an open challenge with potential applications in life sciences and advanced manufacturing. Magnetism has been studied as a means to perform such fine scale manipulation, but generating fields that discriminate between targets at small length scales is nontrivial. We present(More)
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