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Biological activities of a recombinant adenovirus p53 (SCH 58500) administered by hepatic arterial infusion in a Phase 1 colorectal cancer trial
The major focus of intrahepatic arterial (IHA) administration of adenoviruses (Ad) has been on safety. Currently, there is little published data on the biological responses to Ad when administered… Expand
Assessment of p53 gene transfer and biological activities in a clinical study of adenovirus-p53 gene therapy for recurrent ovarian cancer
A cohort study was designed to evaluate the efficiency of gene transfer and whether biological activity from the expressed therapeutic gene resulted after administration of a recombinant adenovirus… Expand
Adenoviral Delivery of Human and Viral IL-10 in Murine Sepsis1
Adenovirus (Ad) gene therapy has been proposed as a drug-delivery system for the targeted administration of protein-based therapies, including growth factors and biological response modifiers.… Expand
Interferon α2b gene delivery using adenoviral vector causes inhibition of tumor growth in xenograft models from a variety of cancers
A recombinant adenovirus expressing human interferon α2b driven by the cytomegalovirus promoter, IACB, was shown to produce and secrete biologically active protein in vitro and in vivo. Intravenous… Expand
Adenovirus-Mediated Gene Therapy Using Human p21WAF-1/Cip-1to Prevent Wound Healing in a Rabbit Model of Glaucoma Filtration Surgery
Objective To determine if adenovirus-mediated p21 WAF-1/Cip-1 (p21) gene therapy can prevent fibroproliferation and wound healing in a rabbit model of glaucoma filtration surgery. Methods In vitro… Expand
Adenovirus-mediated gene therapy using human p21WAF-1/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgery.
OBJECTIVE To determine if adenovirus-mediated p21(WAF-1/Cip-1) (p21) gene therapy can prevent fibroproliferation and wound healing in a rabbit model of glaucoma filtration surgery. METHODS In vitro… Expand
Adenovirus-Mediated Gene Therapy Using Human p 21 WAF-1 / Cip-1 to Prevent Wound Healing in a Rabbit Model of Glaucoma Filtration Surgery
Methods: In vitro studies were performed using rabbit Tenon fibroblasts harvested from fresh tissue. In vivo studies were conducted in New Zealand white rabbits. A fullthickness sclerotomy was… Expand