Jeremy S. Ditelberg

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BACKGROUND We conducted a study to determine the prevalence and factors associated with hepatic steatosis in human immunodeficiency virus (HIV)-seropositive patients with hepatitis C and to investigate whether steatosis is associated with liver fibrosis. METHODS Retrospective chart reviews were conducted in 4 hospitals that serve community-based and(More)
Patients with longstanding and extensive ulcerative colitis (UC) and Crohn’s disease of the colon have an increased risk of developing colorectal cancer (CRC). A meta-analysis published in 2001 including 116 studies from around the world reported the risk of CRC in patients with UC as 2% after 10 years, 8% after 20 years, and 18% after 30 years of disease.(More)
The detection and removal of advanced colonic polyps (ACPs) can help prevent the development of colorectal cancer. A set of DNA mutations known to be associated with colorectal carcinoma was tested against resected ACPs to determine the set s potential utility as a marker panel for ACPs. A sensitive mutation marker panel could be used by stool-based assays(More)
Unlike the mature animal, immature mice transgenic for copper/zinc superoxide dismutase (SOD1) have greater brain injury after hypoxia-ischemia than their wild-type nontransgenic littermates. To assess the role of oxidative stress in the pathogenesis of this injury, we measured histopathological damage, lipid peroxidation products, enzymatic activities of(More)
The role of superoxide radical formation in the pathogenesis of perinatal hypoxic-ischemic injury was examined using transgenic (Tg) mice expressing three times normal amounts of copper/zinc-superoxide dismutase (CuZn/SOD). Fourteen litters of postnatal d 7 strain 218/3 mice were subjected to right common carotid artery ligation followed by 90 min of(More)
BACKGROUND Trichilemmoma (TL) can occur as a solitary sporadic lesion usually on the face or as multiple facial lesions almost invariably associated with Cowden syndrome (CS). CS is a multisystem disorder caused by a germline inactivating mutation in PTEN (10q23.31), a tumor suppressor gene. We sought to identify PTEN loss by immunohistochemistry (IHC) in(More)
A 48-year-old female presented with 8 weeks of generalized pruritis in April 1988. The serum alkaline phosphatase (ALP) was 909 IU; total bilirubin, 3.1 mg/dl; alanine aminotransferase (ALT), 187 U/L; serum albumin, 4.2 g/dl; and antimitochondrial antibody (AMA) positive, titer 1:320. Cholestyramine was prescribed and she was referred to Tufts–New England(More)
Glucocorticoids are one of the few (classes of) drugs that have not been associated with hepatic injury. Glucocorticoids are widely used to treat a variety of diseases, usually immunologically mediated, including autoimmune chronic hepatitis. Although their long-term use is associated with a wide variety of unwanted side effects, liver disease is not one of(More)
Folate depletion and aging are risk factors for colorectal cancer. We investigated the effects of folate status and aging on gene expression in the rat colon. Young (weanling) and older (12 month) rats were fed folic acid depleted (0 mg/kg) and supplemented (8 mg/kg) diets for 20 weeks. Gene expression was measured in colonic mucosal scrapings (n = 3 per(More)
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