Jeremy R Fry

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When paracetamol (1.5 g) was administered orally to non-fasted healthy subjects, statistically significantly more paracetamol glucuronide was detected in 0-4 h urine when the drug was given at 8.00 a.m. as compared to other times of the day. Compared to administration at 8.00 pm, the urine contained almost twice as much glucuronide. However, there was(More)
Plasma and saliva paracetamol levels were measured by HPLC in ten healthy volunteers who took a therapeutic dose after an overnight fast. Salivary levels of the drug were consistently and significantly higher than those in plasma for the first 50 min after oral ingestion, but saliva and plasma levels correlated closely during the elimination phase. There(More)
  • Jeremy R Fry
  • Xenobiotica; the fate of foreign compounds in…
  • 1987
1. The metabolism of 4-methoxybiphenyl to 4-hydroxybiphenyl and its sulphate and glucuronic acid conjugates has been studied in rat isolated hepatocytes at various concentrations of 4-methoxybiphenyl. 2. The proportions of metabolites produced remained constant at concentrations of 4-methoxybiphenyl less than 25-50 microM, but at higher concentrations the(More)
OBJECTIVE Unusual long-wave cycles in the position of an erupting human premolar were first noted by Trentini et al. [Trentini CJ, Brown WH, Paterson RL, Proffit WR. The application of Moire magnification to high precision studies of human premolar eruption. Arch Oral Biol 1995;40:623-9]. This report characterises them in detail and evaluates their(More)
Protein and N-linked glycoprotein biosynthesis was studied in the uninvolved epidermis of patients with psoriasis by the incorporation of radiolabelled leucine and mannose prior to and during PUVA treatment. Analysis of the polyacrylamide gel electrophoresis (PAGE) patterns of the 3[H]-labelled proteins and glycoproteins showed that the major changes in(More)
Protein and N-linked glycoprotein biosynthesis was studied in histologically verified normal epidermis, actinic keratoses, keratoacanthoma, intra-epidermal carcinoma and squamous-cell carcinoma using polyacrylamide gel electrophoresis (PAGE). The PAGE profiles of 3[H]-leucine-labelled proteins and 3[H]-mannose-labelled glycoprotein from all disease states(More)
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