Jeremy Presland

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Allosteric intervention at G protein-coupled receptors is considered an alternative approach to developing new drugs for both classical and novel biological targets. Allosteric compounds, which by definition bind at sites spatially separated from those of the endogenous ligands, may offer benefits over orthosteric ligands in terms of providing therapeutic(More)
Historically, the activation and inhibition of GPCR (G-protein-coupled receptor) function have been a very successful avenue for drug discovery and development. However, it is clear that receptors do not function in isolation but are impacted by other proteins. These proteins may alter either binding or functional responses. Identification and study of(More)
The concept of G-protein-coupled receptor (GPCR) oligomerization has existed for many years, but has only recently received scrutiny from the pharmaceutical industry. The new interest in this theory has arisen not only because technologies to exploit GPCR oligomers are now available, but also because GPCR oligomerization has the potential to explain(More)
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