Jeremy P. Kemmerer

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One way to assess the efficacy of thermal therapy is to quantify changes in tissue properties through ultrasonic interrogation, which requires knowledge of the acoustic properties of thermally treated tissues. In this study, estimates of ultrasonic attenuation, speed of sound, backscatter coefficient (BSC), and scattering property estimates were generated(More)
Nonalcoholic fatty liver disease (NAFLD) affects more than 30% of Americans, and with increasing problems of obesity in the United States, NAFLD is poised to become an even more serious medical concern. At present, accurate classification of steatosis (fatty liver) represents a significant challenge. In this study, the use of high-frequency (8 to 25 MHz)(More)
Quantitative ultrasound (QUS) imaging is hypothesized to map temperature elevations induced in tissue with high spatial and temporal resolution. To test this hypothesis, QUS techniques were examined to monitor high-intensity focused ultrasound (HIFU) exposure of tissue. In situ experiments were conducted on mammary adenocarcinoma tumors grown in rats and(More)
Fischer 344 rats with subcutaneous mammary adenocarcinoma tumors were exposed to therapeutic ultrasound at one of three exposure levels (335, 360, and 502 W/cm(2) spatial-peak temporal-average intensity). Quantitative ultrasound estimates were generated from ultrasound radio frequency (RF) data from tumors before and after high-intensity focused ultrasound(More)
Quantitative ultrasound (QUS) is a novel imaging technique that is hypothesized to be capable of monitoring of High Intensity Focused Ultrasound (HIFU) treatment by quantifying tissue changes during exposure. Experiments were conducted on fresh liver samples from rats and lesions were formed using a HIFU system (1-MHz, f/1.2). A wire thermocouple was(More)
Thermal ablation and hyperthermia remain as potent treatment options for cancer. However, the inability to closely monitor temperature elevations from thermal therapies in real time continues to limit clinical applicability. Therefore, the development of new imaging techniques capable of providing feedback and temperature monitoring is highly medically(More)
High-intensity focused ultrasound (HIFU) is a promising means of non-invasive therapy for the treatment of tumors. Monitoring and assessment challenges for HIFU therapy remain, however, and ultrasound is under investigation to accomplish non-invasive treatment feedback. Quantitative ultrasound (QUS) was investigated for acute HIFU therapy assessment as well(More)
Quantitative ultrasound techniques are generally applied to characterize media whose scattering sites are considered to be small compared to a wavelength. In this study, the backscattered response of single weakly scattering spheres and cylinders with diameters comparable to the beam width of a 2.25 MHz single-element transducer were simulated and measured(More)
The success of any minimally invasive treatment procedure can be enhanced significantly if combined with a robust noninvasive imaging modality that can monitor therapy in real time. Quantitative ultrasound (QUS) imaging has been widely investigated for monitoring various treatment responses such as chemotherapy, radiation, and thermal therapy. Previously,(More)
Quantitative ultrasound (QUS) is a novel approach for characterizing tissue microstructure and changes in tissue microstructure due to therapy. In this report, we discuss changes in QUS parameters in liver tissues after being exposed to thermal insult. Effective scatterer diameter (ESD) and effective acoustic concentration (EAC) from the normalized(More)
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