Jeremy Jerome Laukka

Learn More
Earlier work in this laboratory showed that amiodarone induces apoptosis in alveolar epithelial cells by a mechanism inhibitable by angiotensin system antagonists. A variety of recent studies suggests a critical role for alveolar epithelial cell apoptosis in the pathogenesis of lung fibrosis. On this basis we hypothesized that amiodarone-induced alveolar(More)
Pelizaeus-Merzbacher disease (PMD) is an X-linked inherited hypomyelinating disorder caused by mutations in the gene encoding proteolipid protein (PLP), the major structural protein in central nervous system (CNS) myelin. Prior to our study, whether hypomyelination in PMD was caused by demyelination, abnormally thin sheaths or failure to form myelin was(More)
OBJECTIVE To determine whether quantitative measure of magnetic resonance imaging data from patients with the inherited leukodystrophy, Pelizaeus-Merzbacher disease (PMD) correlates with clinical severity or progression. METHODS In our current work we have analyzed the clinical phenotypes and MRI scans of 51 male patients with PMD and 10 female carriers(More)
Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder of the central nervous system (CNS) caused by a wide variety of mutations affecting proteolipid protein 1 (PLP1). We assessed the effects of PLP1 mutations on water diffusion in CNS white matter by using diffusion tensor imaging. Twelve patients with different PLP1 point mutations encompassing a(More)
Earlier work in this laboratory showed that noradrenaline (NA) induces apoptosis in primary cultures of alveolar epithelial cells (AECs). Apoptosis of alveolar epithelial cells may promote the collapse of lung barrier function. On this basis we hypothesized that exogenous NA, administered by intratracheal (I.T.) instillation, might induce AEC apoptosis in(More)
Pelizaeus-Merzbacher disease (PMD) is a pediatric disease of myelin in the central nervous system and manifests with a wide spectrum of clinical severities. Although PMD is a rare monogenic disease, hundreds of mutations in the X-linked myelin gene proteolipid protein 1 (PLP1) have been identified in humans. Attempts to identify a common pathogenic process(More)
More than a century ago, in 1885 Friedrich Pelizaeus, a German Physician first identified a genetic disorder in five boys in a single family with nystagmus, spasticity of the limbs and developmental delay [1]. Twenty-five years later in 1910, Ludwig Merzbacher independently reexamined this family and described further the neuropathology of 14 affected(More)
DEDICATION This work is dedicated to my father, Warren J. Laukka and to my mother Donna Mae Laukka who served and blessed my life with love, faith and commitment to see that I become an individual of integrity and virtuous principles. I also wish to dedicate this work to my beloved wife, Nicole L. Laukka for her unwavering support and commitment to our(More)
  • 1