Jeremy J Kodanko

Publications59
h-index18
Citations1,105
Highly Influential Citations8
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Novel Polypyridyl chelators deplete cellular zinc and destabilize the X‐linked inhibitor of apoptosis protein (XIAP) prior to induction of apoptosis in human prostate and breast cancer cells
X‐linked inhibitor of apoptosis protein (XIAP), inhibits the initiation and execution phases of the apoptotic pathway. XIAP is the most potent member of the inhibitor of apoptosis protein (IAP)… Expand
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Light activation of a cysteine protease inhibitor: caging of a peptidomimetic nitrile with Ru(II)(bpy)2.
A novel method for caging protease inhibitors is described. The complex [Ru(II)(bpy)(2)(1)(2)](PF(6))(2) (2) was prepared from the nitrile-based peptidomimetic inhibitor Ac-Phe-NHCH(2)CN (1). (1)H… Expand
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Synthesis, characterization, and reactivity of the stable iron carbonyl complex [Fe(CO)(N4Py)](ClO4)2: photoactivated carbon monoxide release, growth inhibitory activity, and peptide ligation.
Photoactivated carbon monoxide (CO) release by the iron carbonyl complex [Fe(II)(CO)(N4Py)](ClO(4))(2) (1) is described. Compound 1 is a low-spin ferrous complex that is highly stable and soluble in… Expand
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Inhibition of Cathepsin Activity in a Cell‐Based Assay by a Light‐Activated Ruthenium Compound
Light‐activated inhibition of cathepsin activity was demonstrated in a cell‐based assay. Inhibitors of cathepsin K, Cbz‐Leu‐NHCH2CN (2) and Cbz‐Leu‐Ser(OBn)‐CN (3), were caged within the complexes… Expand
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Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition.
Photochemical control over irreversible inhibition was shown using Ru(ii)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(ii) complex was attached to the organic… Expand
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Asymmetric synthesis of pyrrolidinoindolines. Application for the practical total synthesis of (-)-phenserine.
A versatile route to enantiopure 3,3-disubstituted oxindoles and 3a-substituted pyrrolidinoindolines is described in which diastereoselective dialkylation of enantiopure ditriflate 10 with oxindole… Expand
  • 124
Catalytic asymmetric synthesis of quaternary carbons bearing two aryl substituents. Enantioselective synthesis of 3-alkyl-3-aryl oxindoles by catalytic asymmetric intramolecular heck reactions.
A practical sequence involving three consecutive palladium(0)-catalyzed reactions has been developed for synthesizing 3-alkyl-3-aryloxindoles in high enantiopurity. The Heck cyclization precursors 10… Expand
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Ruthenium Tris(2-pyridylmethyl)amine as an Effective Photocaging Group for Nitriles
Ruthenium(II) tris(2-pyridylmethyl)amine (TPA) is an effective caging group for nitriles that provides high levels of control over the enzyme activity with light. Two caged nitriles were prepared,… Expand
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Enantioselective total syntheses of the cyclotryptamine alkaloids hodgkinsine and hodgkinsine B.
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New Ru(II) Complex for Dual Activity: Photoinduced Ligand Release and (1)O2 Production.
The new complex [Ru(pydppn)(biq)(py)](2+) (1) undergoes both py photodissociation in CH3CN with Φ500 =0.0070(4) and (1)O2 production with ΦΔ =0.75(7) in CH3 OH from a long-lived (3) ππ* state… Expand
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