Jeremy Choon-Meng Teo

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Visualizing the dynamic behaviors of immune cells in living tissue has dramatically increased our understanding of how cells interact with their surroundings, contributing important insights into mechanisms of leukocyte trafficking, tumor cell invasion, and T cell education by dendritic cells, among others. Despite substantial advances with various(More)
The migration of cells such as leukocytes, tumor cells, and fibroblasts through 3D matrices is critical for regulating homeostasis and immunity and for driving pathogenesis. Interstitial flow through the extracellular matrix, which can substantially increase during inflammation and in the tumor microenvironment, can influence cell migration in multiple(More)
There is a need for the development of finite element (FE) models based on medical datasets, such as magnetic resonance imaging and computerized tomography in computation biomechanics. Direct conversion of graphic voxels to FE elements is a commonly used method for the generation of FE models. However, conventional voxel-based methods tend to produce models(More)
Keywords: Component-oriented software development Finite element mesh generation Biomechanical modeling and simulation a b s t r a c t A component-oriented software system, i.BioMech (image-based biomechanical modeling) is proposed for generation of patient-specific finite element model. It applies a systematic software engineering approach to(More)
Medical simulators are increasingly being used for surgical training. For interactive surgical simulation involving haptic rendering, the force at the needle tip has to be computed very fast. We are developing biomechanical models for bone needle insertion. The cortical bone can be regarded as a dense form of cancellous bone that can be modeled using a(More)
The significant gap between quantitative and qualitative understanding of cytoskeletal function is a pressing problem; microscopy and labeling techniques have improved qualitative investigations of localized cytoskeleton behavior, whereas quantitative analyses of whole cell cytoskeleton networks remain challenging. Here we present a method that accurately(More)
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