Jeremy C. Wells

Learn More
BACKGROUND The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy. OBJECTIVE To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therapies. DESIGN, SETTING, AND PARTICIPANTS Retrospective(More)
BACKGROUND Sunitinib (SU) and pazopanib (PZ) are standards of care for first-line treatment of metastatic renal cell carcinoma (mRCC). However, how the efficacy of these drugs translates into effectiveness on a population-based level is unknown. PATIENTS AND METHODS We used the International mRCC Database Consortium (IMDC) to assess overall survival (OS),(More)
BACKGROUND Questions about optimal sequencing of systemic therapy in metastatic castration-resistant prostate cancer (mCRPC) and whether cross-resistance occurs between different drugs remain largely unanswered. Previous studies have produced conflicting data on the activity of docetaxel in patients who did not attain a prostate-specific antigen (PSA)(More)
BACKGROUND The use of third-line targeted therapy (TTT) in metastatic renal cell carcinoma (mRCC) is not well characterized and varies due to the lack of robust data to guide treatment decisions. This study examined the use of third-line therapy in a large international population. OBJECTIVE To evaluate the use and efficacy of targeted therapy in a(More)
BACKGROUND Neutrophil-to-lymphocyte ratio (NLR), if elevated, is associated with worse outcomes in several malignancies. OBJECTIVE Investigation of NLR at baseline and during therapy for metastatic renal cell carcinoma. DESIGN, SETTING, AND PARTICIPANTS Retrospective analysis of 1199 patients from the International Metastatic Renal Cell Carcinoma(More)
PURPOSE Glioblastoma is one of the most lethal cancers in humans, and with existing therapy, survival remains at 14.6 months. Current barriers to successful treatment include their infiltrative behavior, extensive tumor heterogeneity, and the presence of a stem-like population of cells, termed brain tumor-initiating cells (BTIC) that confer resistance to(More)
This paper discusses pronunciation research using a written questionnaire to ask people overt questions about their pronunciation. Several investigations that have used this approach are discussed. The technique is particularly useful for large-scale surveys of variability in lexical incidence or in the phonological system. It is unsuitable for surveying(More)
This paper analyzes international heritage conservation charters through the poststructuralist lens of relative and perspective-driven “truths,” fragmentation, and dramatic settings. The “SPAB Manifesto,” the Athens Charter, the Venice Charter, the Burra Charter, and the Nara Document on Authenticity are evaluated within the framework of discursive theories(More)
Unicode provides a single coding system for all scripts used in printing the languages of the world, and includes the entire International Phonetic Alphabet. A standard Unicode-based phonetic font is now routinely bundled with the software supplied for new personal computers. Unlike the situation four years ago, most current browsers, word-processing(More)
Chronic pain is a debilitating and degrading condition. Its aetiology is largely multifactorial, and only proper appreciation of the various factors which can combine to produce the patient's misery will allow appropriate therapies. If the mechanisms of chronic pain were better taught and the therapies available were better used by medical practitioners,(More)