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- Tathagata Dasgupta, David H. Croll, +5 authors Jeremy Gunawardena
- The Journal of Biological Chemistry
- 2014

Background: Covalent modification cycles are widely used as regulatory switches. Results: Mathematical analysis reveals, under very general assumptions, an unavoidable trade-off between switching… (More)

- Jeremy A. Owen, Artemy Kolchinsky, David H. Wolpert
- ArXiv
- 2017

We consider the problem of implementing a given conditional distribution relating the states of a physical system at two separate times using a physical process with (potentially time-inhomogeneous)… (More)

- David H. Wolpert, Artemy Kolchinsky, Jeremy A. Owen
- ArXiv
- 2017

We consider the problem of constructing a physical system that evolves according to some specified conditional distribution. We restrict attention to physical systems that can be modeled as a… (More)

- Tal Kachman, Jeremy A. Owen, Jeremy L. England
- Physical review letters
- 2017

Recent studies of active matter have stimulated interest in the driven self-assembly of complex structures. Phenomenological modeling of particular examples has yielded insight, but general… (More)

- David H. Wolpert, Artemy Kolchinsky, Jeremy A. Owen
- Nature Communications
- 2019

Master equations are commonly used to model the dynamics of physical systems, including systems that implement single-valued functions like a computer’s update step. However, many such functions… (More)

- Ian M. Overton, Andrew H Sims, +5 authors Abdelkader Essafi
- 2018

Background: Cell identity is governed by gene expression, regulated by Transcription Factor (TF) binding at cis-regulatory modules. Decoding the relationship TF binding patterns and the regulation of… (More)

One of the basic characteristics of any physical system is its response to small perturbations. For instance, response is used to quantify material properties--such as conductivity and… (More)

- David H. Wolpert, Artemy Kolchinsky, Jeremy A. Owen
- Nature Communications
- 2019

The original version of the Supplementary Information associated with this Article contained an error throughout in which all inline references to Theorems, Definitions and Lemmas given in the main… (More)