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- Yongming Ren, Min Young Lee, +9 authors Yibing Qyang
- Journal of molecular and cellular cardiology
- 2011
Human induced pluripotent stem (iPS) cells potentially provide a unique resource for generating patient-specific cardiomyocytes to study cardiac disease mechanisms and treatments. However, existing… (More)
- Jere Paavola, Matti Viitasalo, +6 authors Mika Laine
- European heart journal
- 2007
AIMS
Mutations in cardiac ryanodine receptors (RyR2s) are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT), characterized by risk of polymorphic ventricular tachyarrhythmias and… (More)
- Kirsi Kujala, Jere Paavola, +10 authors Katriina Aalto-Setälä
- PloS one
- 2012
BACKGROUND
Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of genetic disorders. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a malignant inherited… (More)
- Kirsi Penttinen, Heikki Swan, +4 authors Katriina Aalto-Setälä
- PloS one
- 2015
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations… (More)
- Surjya Narayan Dash, E Lehtonen, +5 authors Sanna Lehtonen
- Journal of cell science
- 2014
The conserved septin family of filamentous small GTPases plays important roles in mitosis, cell migration and cell morphogenesis by forming scaffolds and diffusion barriers. Recent studies in… (More)
- Min Young Lee, Baonan Sun, +12 authors Yibing Qyang
- Stem cell research
- 2012
The purpose of this study is to establish a murine embryonic stem cell (mESC) line for isolation of functional ventricular cardiomyocytes (VCMs) and then to characterize the derived VCMs. By crossing… (More)
- Jere Paavola, Simon Schliffke, +6 authors Barbara E Ehrlich
- Journal of molecular and cellular cardiology
- 2013
Mutations in PKD1 and PKD2, the genes encoding the proteins polycystin-1 (PC1) and polycystin-2 (PC2), cause autosomal dominant polycystic kidney disease (ADPKD). Although the leading cause of… (More)
- Kirsi Penttinen, Heikki Swan, +4 authors Katriina Aalto-Setälä
- PloS one
- 2015
There are errors in Fig 2, " Features of the PVCs, " and its caption. Please see the corrected Fig 2 and its caption here. Copyright: © 2015 Penttinen et al. This is an open access article… (More)
- Surjya Narayan Dash, Suneeta Narumanchi, +5 authors Sanna Lehtonen
- American journal of physiology. Heart and…
- 2017
Myofibrils made up of actin, myosin, and associated proteins generate the contractile force in muscle, and, consequently, mutations in these proteins may lead to heart failure. Septins are a… (More)
- Yan Chen, Jere Paavola, +4 authors Yrjö T. Konttinen
- European journal of pharmacology
- 2015
Histamine is a neurotransmitter and chemical mediator in multiple physiological processes. Histamine H3 receptor is expressed in the nervous system, heart, and gastrointestinal tract; however, little… (More)